Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis

REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) Collaborators; Thomas, Shirley

Abstract

Background: The factors associated with recovery of language domains affected by stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming and functional-communication across participants’ age, sex and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data (IPD) meta-analysis of systematically-sourced aphasia datasets described overall-language-ability using the Western Aphasia Battery Aphasia-Quotient (WAB-AQ); auditory comprehension by Aachen Aphasia Test Token Test (AAT-TT); naming by Boston Naming Test (BNT) and functional-communication by AAT Spontaneous-Speech Communication subscale (AAT-SC). Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in RCTs and all study types. Change-from-baseline scores were presented as estimates of means and 95% confidence intervals (CI). Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks post-stroke; interquartile range (IQR) [4-165.1]) and first-follow-up (median=10 weeks from baseline; IQR [3, 26]) were available for n=943 on overall-language-ability, n=1,056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (

Citation

REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) Collaborators, & Thomas, S. (2021). Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis. Stroke, 52(5), 1778–1787. https://doi.org/10.1161/STROKEAHA.120.031162

• Journal Article Type: Article
• Acceptance Date: Dec 15, 2020
• Online Publication Date: Mar 15, 2021
• Publication Date: 2021-05
• Deposit Date: Mar 10, 2021
• Publicly Available Date: Sep 16, 2021
• Journal: Stroke
• Print ISSN: 0039-2499
• Electronic ISSN: 1524-4628
• Publisher: American Heart Association
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 5
• Pages: 1778–1787
• DOI: https://doi.org/10.1161/STROKEAHA.120.031162
• Public URL: https://nottingham-repository.worktribe.com/output/5383480
• Publisher URL: https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031162
• Additional Information: Full list of collaborators in appendix .