Passive control of temperature distribution in cancerous tissue during photothermal therapy using optical phase change nanomaterials

Ren, Yatao; Chen, Qin; Li, Huaxin; Qi, Hong; Yan, Yuying

Abstract

Thermal therapy is a very promising alternative treatment for benign tumor, in which the temperature control is a key issue to avoid unwanted thermal damage of healthy tissue. However, the active temperature control methods usually require the assistance of real-time and accurate temperature monitoring devices. Even though, the lag of temperature control is inevitable. Therefore, in the present work, a passive control method is proposed to improve the uniformity of temperature distribution inside tumorous tissue during laser induced thermal therapy (LITT). Optical phase change nanoparticles (O-PCNPs) are utilized to replace the commonly used noble metal nanoparticles to enhance and adjust the localized light absorption in tumor. In the early stage of LITT, the O-PCNPs is used to improve the specific absorption rate in the targeted region. However, after the local temperature reaches a certain level (phase transition temperature), the O-PCNPs convert from amorphous state to crystalline state. By carefully selecting the size, shape, and laser wavelength, the absorption cross section of O-PCNPs could drop dramatically after phase transition. Therefore, in the high temperature zone the local temperature increasing rate reduces due to the reduction of local heat generation rate. On the contrary, the temperature increasing rate rises in the low temperature zone since more energy is transferred to the deeper tissue. In the present work, results show that SiO2@VO2 nanoshells can be applied as thermal contrast agents to improve the temperature uniformity in tumor during LITT.

Citation

Ren, Y., Chen, Q., Li, H., Qi, H., & Yan, Y. (2021). Passive control of temperature distribution in cancerous tissue during photothermal therapy using optical phase change nanomaterials. International Journal of Thermal Sciences, 161, Article 106754. https://doi.org/10.1016/j.ijthermalsci.2020.106754

• Journal Article Type: Article
• Acceptance Date: Nov 19, 2020
• Online Publication Date: Nov 28, 2020
• Publication Date: 2021-03
• Deposit Date: Feb 5, 2021
• Publicly Available Date: Nov 29, 2021
• Journal: International Journal of Thermal Sciences
• Print ISSN: 1290-0729
• Electronic ISSN: 1778-4166
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 161
• Article Number: 106754
• DOI: https://doi.org/10.1016/j.ijthermalsci.2020.106754
• Keywords: Thermal therapy; optical phase change nanoparticles; light and heat transfer; passive control; VO2
• Public URL: https://nottingham-repository.worktribe.com/output/5293811
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S1290072920311984
• Additional Information: This article is maintained by: Elsevier; Article Title: Passive control of temperature distribution in cancerous tissue during photothermal therapy using optical phase change nanomaterials; Journal Title: International Journal of Thermal Sciences; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.ijthermalsci.2020.106754; Content Type: article; Copyright: © 2020 Elsevier Masson SAS. All rights reserved.