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Y-box binding protein-1: A neglected target in pediatric brain tumors?

Taylor, Louisa; Kerr, Ian D.; Coyle, Beth

Y-box binding protein-1: A neglected target in pediatric brain tumors? Thumbnail


Authors

Louisa Taylor

IAN KERR ian.kerr@nottingham.ac.uk
Associate Professor

BETH COYLE BETH.COYLE@NOTTINGHAM.AC.UK
Associate Professor



Abstract

© 2020 American Association for Cancer Research. Brain and central nervous system tumors represent the most common childhood solid tumors. Comprising 21% of all pediatric cancers, they remain the leading cause of cancer-related mortality and morbidity in childhood. Due to advances in neurosurgical technique, radiotherapy and the use of combination therapy, survival rates have generally increased. However, by cause of the lesion itself, its surgical removal and subsequent treatment, survivors are at high risk of long-term neurocognitive sequelae and secondary cancer. Clearly, improvements in diagnosis and treatment are needed. Accordingly, current treatment is evolving away from conventional, uniform therapy and towards risk-stratified regimens and molecularly-targeted therapies, with the aim of diminishing adverse side effects while minimizing the risk of disease recurrence. The multifunctional oncoprotein Y-box binding protein 1 (YB-1) may serve as one such molecular target. Increased YB-1 levels have been reported in a number of pediatric brain tumors, where YB-1 appears to facilitate the advancement of malignant phenotypes. These include proliferation, invasion, and resistance to therapy, as well as the maintenance of brain tumor-initiating cells. Here we evaluate the current literature and show how YB-1 modulates signaling pathways driving each of these phenotypes. We also review the regulation of YB-1 at a transcriptional, translational, posttranslational and subcellular level and argue that there is strong and sufficient evidence to support the development of YB-1 as a biomarker and future therapeutic target in childhood brain tumors.

Citation

Taylor, L., Kerr, I. D., & Coyle, B. (2021). Y-box binding protein-1: A neglected target in pediatric brain tumors?. Molecular Cancer Research, 19(3), 375-387. https://doi.org/10.1158/1541-7786.MCR-20-0655

Journal Article Type Article
Acceptance Date Nov 20, 2020
Online Publication Date Nov 25, 2020
Publication Date Mar 1, 2021
Deposit Date Nov 30, 2020
Publicly Available Date Nov 26, 2021
Journal Molecular Cancer Research
Print ISSN 1541-7786
Electronic ISSN 1557-3125
Publisher American Association for Cancer Research
Peer Reviewed Peer Reviewed
Volume 19
Issue 3
Pages 375-387
DOI https://doi.org/10.1158/1541-7786.MCR-20-0655
Keywords Cancer Research; Oncology; Molecular Biology
Public URL https://nottingham-repository.worktribe.com/output/5088621
Publisher URL https://mcr.aacrjournals.org/content/early/2020/11/25/1541-7786.MCR-20-0655

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