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Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer

Morotti, Matteo; Zois, Christos E.; El-Ansari, Rokaya; Craze, Madeleine L.; Rakha, Emad A.; Fan, Shih-Jung; Valli, Alessandro; Haider, Syed; Goberdhan, Deborah C. I.; Green, Andrew R.; Harris, Adrian L.

Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer Thumbnail


Authors

Matteo Morotti

Christos E. Zois

Rokaya El-Ansari

Madeleine L. Craze

Shih-Jung Fan

Alessandro Valli

Syed Haider

Deborah C. I. Goberdhan

Adrian L. Harris



Citation

Morotti, M., Zois, C. E., El-Ansari, R., Craze, M. L., Rakha, E. A., Fan, S.-J., Valli, A., Haider, S., Goberdhan, D. C. I., Green, A. R., & Harris, A. L. (2021). Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. British Journal of Cancer, 124(2), 494-505. https://doi.org/10.1038/s41416-020-01113-y

Journal Article Type Article
Acceptance Date Sep 17, 2020
Online Publication Date Oct 8, 2020
Publication Date Jan 19, 2021
Deposit Date Jun 22, 2021
Publicly Available Date Jun 22, 2021
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 124
Issue 2
Pages 494-505
DOI https://doi.org/10.1038/s41416-020-01113-y
Keywords Cancer Research; Oncology
Public URL https://nottingham-repository.worktribe.com/output/4949891
Publisher URL https://www.nature.com/articles/s41416-020-01113-y
Additional Information Received: 10 May 2020; Revised: 10 September 2020; Accepted: 17 September 2020; First Online: 8 October 2020; : This work obtained ethics approval by the North West-Greater Manchester Central Research Ethics Committee under the title: Nottingham Health Science Biobank (NHSB), reference number 15/NW/0685. All patients included were consented to participate in the study and to use their materials in research. All samples from Nottingham used in this study were pseudo-anonymised and stored in compliance with the UK Human Tissue Act. The study was performed in accordance with the Declaration of Helsinki; : Not applicable.; : The data presented in the current study are available upon reasonable request from the corresponding author.; : The authors declare no competing interests.; : This research was supported by funding from Cancer Research UK (C19591/A19076; D.C.I.G.), Oxford NIHR Biomedical Research Centre, Breast Cancer Research Foundation (A.L.H.), Kennington Cancer Fund (A.L.H.) and by a Fondazione Veronesi fellowship (to M.M.).

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