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New models of adipogenic differentiation highlight a cell-autonomous response to temperature

Velickovic, K.; Lugo Leija, H.A.; McGinlay, S.; Symonds, M.E.; Sottile, V.

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Authors

K. Velickovic

H.A. Lugo Leija

S. McGinlay

M.E. Symonds

V. Sottile



Abstract

Temperature is a key regulator of brown adipose tissue (BAT) function, acting through central sensory inputs to influence metabolism and energy storage. Although animal models have produced a wealth of information on the pathways, effectors and responses mediating the physiological response of adipose tissue to temperature in vivo, the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes, in the absence of neural input. In particular, stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro. Here the basis for adipogenic responsiveness to low temperature is discussed, together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.

Citation

Velickovic, K., Lugo Leija, H., McGinlay, S., Symonds, M., & Sottile, V. (2020). New models of adipogenic differentiation highlight a cell-autonomous response to temperature. Biocell, 44(4), 501-512. https://doi.org/10.32604/biocell.2020.012942

Journal Article Type Article
Acceptance Date Sep 25, 2020
Online Publication Date Dec 24, 2020
Publication Date Dec 24, 2020
Deposit Date Oct 1, 2020
Publicly Available Date Dec 24, 2020
Journal Biocell
Print ISSN 0327-9545
Electronic ISSN 1667-5746
Publisher Tech Science Press
Peer Reviewed Peer Reviewed
Volume 44
Issue 4
Pages 501-512
DOI https://doi.org/10.32604/biocell.2020.012942
Public URL https://nottingham-repository.worktribe.com/output/4936435
Publisher URL https://www.techscience.com/biocell/v44n4/41004

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