Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores

Mitchell, Nicholas J.; Howorka, Stefan

Abstract

The base resolution in the detection of single DNA strands with nanopores can be improved by attaching chemical tags to individual bases. Different chemical tags give rise to characteristic current signatures when a DNA molecule passes through a nanopore (see picture). This sequence?specific sensing with modified DNA is independent of pore engineering and can potentially be applied to analyze nucleic acids with a wide range of solid?state nanopores.

Citation

Mitchell, N. J., & Howorka, S. (2008). Chemical Tags Facilitate the Sensing of Individual DNA Strands with Nanopores. Angewandte Chemie International Edition, 47(30), 5565-5568. https://doi.org/10.1002/anie.200800183

• Journal Article Type: Article
• Online Publication Date: Jun 13, 2008
• Publication Date: Jul 14, 2008
• Deposit Date: Aug 31, 2020
• Journal: Angewandte Chemie International Edition
• Print ISSN: 1433-7851
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 47
• Issue: 30
• Pages: 5565-5568
• DOI: https://doi.org/10.1002/anie.200800183
• Keywords: General Chemistry; Catalysis
• Public URL: https://nottingham-repository.worktribe.com/output/4871600
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200800183