Chemical Tags Mediate the Orthogonal Self-Assembly of DNA Duplexes into Supramolecular Structures

Mitchell, Nicholas J.; Ebner, Andreas; Hinterdorfer, Peter; Tamp�, Robert; Howorka, Stefan

Abstract

A new chemical approach that achieves ordered self?assembly of biomolecules is reported. The chemical tags bis?nitrilotriacetic acid (bisNTA) and hexahistidine (His6) are attached to DNA duplexes that self?assemble into supramolecular structures whose subunits are held together by Ni2?bisNTA?His6?chelate bridges.

• Journal Article Type: Article
• Online Publication Date: Jul 26, 2010
• Publication Date: Aug 16, 2010
• Deposit Date: Aug 31, 2020
• Journal: Small
• Print ISSN: 1613-6810
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 16
• Pages: 1732-1735
• DOI: https://doi.org/10.1002/smll.201000790
• Keywords: Biotechnology; Engineering (miscellaneous); Biomaterials
• Public URL: https://nottingham-repository.worktribe.com/output/4871577