Amphetamine and the adenosine A2A antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats

O'Neill, Martin; Brown, Verity J.

Abstract

As the length of foreperiod preceding an imperative signal increases, reaction time decreases and anticipatory (prior to the signal) responding increases. The authors designed a task to dissociate the effect of elapsing time in the foreperiod and conditional temporal probability of the imperative stimulus. The effects of 2 drugs--amphetamine and KW-6002--known to enhance the effect of foreperiod were compared. Three groups of rats were trained to respond to an auditory signal presented at 1 of 3 foreperiods, unpredictable from trial to trial. The length of preparation time was different for each group, but conditional temporal probability was the same. Reaction times were faster as a function of increased preparation time, whereas anticipatory responses were strongly modulated by conditional probability. Both amphetamine and KW-6002 speeded reaction times and increased anticipatory responding. The pattern of behavior was consistent with the suggestion that they enhanced the motor preparatory effects of conditional probability rather than speeded a timing process. The authors concluded that preparation time and expectancy (conditional temporal probability of an imperative signal) have differential effects on performance and that amphetamine and KW-6002 enhance the effect of expectancy. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved)

Citation

O'Neill, M., & Brown, V. J. (2007). Amphetamine and the adenosine A2A antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats. Behavioral Neuroscience, 121(3), 535-542. https://doi.org/10.1037/0735-7044.121.3.535

• Journal Article Type: Article
• Acceptance Date: Feb 16, 2007
• Publication Date: 2007-06
• Deposit Date: Jul 7, 2020
• Journal: Behavioral Neuroscience
• Print ISSN: 0735-7044
• Electronic ISSN: 1939-0084
• Publisher: American Psychological Association
• Peer Reviewed: Peer Reviewed
• Volume: 121
• Issue: 3
• Pages: 535-542
• DOI: https://doi.org/10.1037/0735-7044.121.3.535
• Keywords: Behavioral Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/4755877
• Publisher URL: https://doi.apa.org/doiLanding?doi=10.1037%2F0735-7044.121.3.535