Are current cancer treatments on target for our ageing cancer population?

Baxter, Mark A.; Cheung, Kwok-Leung; Battisti, Nicolo M.L.

Abstract

Worldwide the cancer population is ageing - within a decade almost two-thirds of newly diagnosed patients will be aged 65 years and older. Despite this, the majority of oncology clinical trials continue to recruit patients who are younger and fitter than those typically encountered in clinical practice. As such, there is a lack of clinical data to guide management, particularly in those patients living with frailty and/or comorbidity. Importantly, the lack of older adults in trials also means that the subsequent translational work that underpins biomarker and therapeutic discovery may not be relevant to those we see in clinic. In this commentary, we discuss this challenge and the ways we as an Oncology community can look to address this pressing issue.

Citation

Baxter, M. A., Cheung, K.-L., & Battisti, N. M. (in press). Are current cancer treatments on target for our ageing cancer population?. Ageing and Cancer Research & Treatment, 1(1), https://doi.org/10.37155/2972-4759-2023-01-01-5

• Journal Article Type: Article
• Acceptance Date: Jun 25, 2023
• Online Publication Date: Jun 30, 2023
• Deposit Date: Mar 14, 2025
• Publicly Available Date: Mar 14, 2025
• Journal: Ageing and Cancer Research & Treatment
• Print ISSN: 2972-4759
• Electronic ISSN: 2972-4767
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 1
• DOI: https://doi.org/10.37155/2972-4759-2023-01-01-5
• Keywords: Geriatric oncology, personalised medicine, translational research
• Public URL: https://nottingham-repository.worktribe.com/output/46469719
• Publisher URL: https://sciexplor.com/articles/2972-4759-2023-01-01-5#null