Daria S. Chulpanova
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
Chulpanova, Daria S.; Kitaeva, Kristina V.; Green, Andrew R.; Rizvanov, Albert A.; Solovyeva, Valeriya V.
Authors
Kristina V. Kitaeva
ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
Albert A. Rizvanov
Valeriya V. Solovyeva
Abstract
Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines, as proteins of the immune system, are able to modulate the host immune response toward cancer cell, as well as directly induce tumor cell death. Since a low dose monotherapy with some cytokines has no significant therapeutic results and a high dose treatment leads to a number of side effects caused by the pleiotropic effect of cytokines, the problem of understanding the influence of cytokines on the immune cells involved in the pro- and anti-tumor immune response remains a pressing one. Immune system cells carry CD makers on their surface which can be used to identify various populations of cells of the immune system that play different roles in pro- and anti-tumor immune responses. This review discusses the functions and specific CD markers of various immune cell populations which are reported to participate in the regulation of the immune response against the tumor. The results of research studies and clinical trials investigating the effect of cytokine therapy on the regulation of immune cell populations and their surface markers are also discussed. Current trends in the development of cancer immunotherapy, as well as the role of cytokines in combination with other therapeutic agents, are also discussed.
Citation
Chulpanova, D. S., Kitaeva, K. V., Green, A. R., Rizvanov, A. A., & Solovyeva, V. V. (2020). Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy. Frontiers in Cell and Developmental Biology, 8, Article 402. https://doi.org/10.3389/fcell.2020.00402
Journal Article Type | Article |
---|---|
Acceptance Date | May 1, 2020 |
Online Publication Date | Jun 3, 2020 |
Publication Date | Jun 3, 2020 |
Deposit Date | Jun 12, 2020 |
Publicly Available Date | Jun 16, 2020 |
Journal | Frontiers in Cell and Developmental Biology |
Electronic ISSN | 2296-634X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Article Number | 402 |
DOI | https://doi.org/10.3389/fcell.2020.00402 |
Public URL | https://nottingham-repository.worktribe.com/output/4631497 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fcell.2020.00402/full |
Files
Cytokines In Cancer Treatment 090320 AG
(1.1 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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