Cumulative incidence of post?infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis

Nguyen?Van?Tam, Jonathan; Wyffels, Veronique; Smulders, Maartje; Mazumder, Debasish; Tyagi, Rohit; Gupta, Nikhil; Gavart, Sandra; Fleischhackl, Roman

Abstract

Background: Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma/wheezing (AW) among term and pre-term infants. We describe the cumulative incidence of AW among hospitalized and ambulatory neonates/infants/toddlers following RSV infection diagnosis over three independent follow-up periods.

Methods: Between January 1, 2007 and March 31, 2016, patients aged 0-2 years old with first clinical diagnosis of RSV infection were identified using the Optum® integrated electronic health records and claims database. Patients diagnosed with AW ≤30 days
post-RSV diagnosis were excluded. Three cohorts with 1, 3 and 5 years of follow-up were stratified by presence or absence of specific RSV high-risk factors, including pre-term birth and pre-defined, pre-existing comorbidities. Descriptive statistics and logistic regression results were reported.

Results: Overall, 9811, 4524 and 1788 RSV-infected high-risk-factor negative patients were included in 1, 3 and 5-year independent cohorts, respectively. Of these, 6.5%, 6.9% and 5.8%, respectively had RSV-related hospitalization. By the end of follow-up, 14.9%, 28.2% and 36.3% had AW events. Overall, 3030, 1378 and 552 RSV-infected high-risk-factor positive patients were included in the respective cohorts. Of these, 11.4%, 11.1% and 11.6%, respectively were hospitalized with initial RSV infection and 18.1%, 32.9% and 37.9% had subsequent AW events within the follow-up period. Logistic regression confirmed RSV-related hospitalization significantly increased the likelihood of developing AW (P

Citation

Nguyen‐Van‐Tam, J., Wyffels, V., Smulders, M., Mazumder, D., Tyagi, R., Gupta, N., …Fleischhackl, R. (2020). Cumulative incidence of post‐infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis. Influenza and Other Respiratory Viruses, 14(6), 730-738. https://doi.org/10.1111/irv.12770

• Journal Article Type: Article
• Acceptance Date: May 28, 2020
• Online Publication Date: Jun 12, 2020
• Publication Date: 2020-11
• Deposit Date: May 29, 2020
• Publicly Available Date: Jun 17, 2020
• Journal: Influenza and Other Respiratory Viruses
• Print ISSN: 1750-2640
• Electronic ISSN: 1750-2659
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 6
• Pages: 730-738
• DOI: https://doi.org/10.1111/irv.12770
• Keywords: Public Health, Environmental and Occupational Health; Epidemiology; Pulmonary and Respiratory Medicine; Infectious Diseases
• Public URL: https://nottingham-repository.worktribe.com/output/4529363
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12770
• Additional Information: Received: 2019-12-20; Accepted: 2020-05-24; Published: 2020-06-12