Skip to main content

Research Repository

Advanced Search

Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach

Evers, Luc J.W.; Raykov, Yordan P.; Heskes, Tom M.; Krijthe, Jesse H.; Bloem, Bastiaan R.; Little, Max A.

Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach Thumbnail


Authors

Luc J.W. Evers

Dr YORDAN RAYKOV Yordan.Raykov@nottingham.ac.uk
ASSISTANT PROFESSOR IN DATA SCIENCE/STATISTICS

Tom M. Heskes

Jesse H. Krijthe

Bastiaan R. Bloem

Max A. Little



Abstract

Objective and continuous monitoring of Parkinson’s disease (PD) tremor in free-living conditions could benefit both individual patient care and clinical trials, by overcoming the snapshot nature of clinical assessments. To enable robust detection of tremor in the context of limited amounts of labeled training data, we propose to use prototypical networks, which can embed domain expertise about the heterogeneous tremor and non-tremor sub-classes. We evaluated our approach using data from the Parkinson@Home Validation study, including 8 PD patients with tremor, 16 PD patients without tremor, and 24 age-matched controls. We used wrist accelerometer data and synchronous expert video annotations for the presence of tremor, captured during unscripted daily life activities in and around the participants’ own homes. Based on leave-one-subject-out cross-validation, we demonstrate the ability of prototypical networks to capture free-living tremor episodes. Specifically, we demonstrate that prototypical networks can be used to enforce robust performance across domain-informed sub-classes, including different tremor phenotypes and daily life activities.

Citation

Evers, L. J., Raykov, Y. P., Heskes, T. M., Krijthe, J. H., Bloem, B. R., & Little, M. A. (2025). Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach. Sensors, 25(2), Article 366. https://doi.org/10.3390/s25020366

Journal Article Type Article
Acceptance Date Dec 23, 2024
Online Publication Date Jan 9, 2025
Publication Date Jan 1, 2025
Deposit Date Feb 7, 2025
Publicly Available Date Feb 7, 2025
Journal Sensors
Electronic ISSN 1424-8220
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 2
Article Number 366
DOI https://doi.org/10.3390/s25020366
Keywords tremor modeling; tremor detection; passive monitoring; wearable sensors; prototype networks; Parkinson’s disease
Public URL https://nottingham-repository.worktribe.com/output/45042027
Publisher URL https://www.mdpi.com/1424-8220/25/2/366

Files





You might also like



Downloadable Citations