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Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort

Bagasi, Arwa A.; Howson-Wells, Hannah C.; Clark, Gemma; Tarr, Alexander W.; Soo, Shiu; Irving, William L.; McClure, C. Patrick


Arwa A. Bagasi

Hannah C. Howson-Wells

Gemma Clark

Shiu Soo


© 2020 Elsevier B.V. Background: Since its first isolation in 2005, Human Bocavirus (HBoV) has been repeatedly associated with acute respiratory tract infections, although its role in pathogenicity remains unclear due to high co-infection rates. Objectives: To assess HBoV prevalence and associated disease in a cohort of respiratory patients in the East Midlands, UK between 2015 and 2019. Study design: We initially investigated the undiagnosed burden of HBoV in a retrospective paediatric cohort sampled between 2015 and 2017 using an in-house PCR assay. HBoV was subsequently incorporated into the standard respiratory diagnostic pathway and we audited a calendar year of HBoV positive results between 2018 and 2019. Results: Our retrospective PCR screening of previously routine diagnostic-negative samples from juvenile patients identified a 9% (n = 30) prevalence of HBoV type 1. These apparent HBoV1 mono-infections were frequently associated with respiratory tract symptoms, often severe requiring ventilation, oxygen and steroid intervention with 31% (n = 9) of individuals requiring intensive care. When HBoV screening was subsequently adopted into the routine respiratory diagnostic pathway, year-round infections were observed in both children and adults peaking in February. 185 of 9098 (2.03%) individuals were found to be HBoV positive with children aged 12–24 months the principally infected group. However, HBoV infection was also observed in patients aged over 60, predominantly as a mono-infection. 23% of the 185 unique patients were HBoV monoinfected and persistent low-level DNA positivity was observed in 15 individuals up to 6-months after initial presentation. Conclusion: HBoV1 is a prevalent respiratory infection in the UK capable of causing serious monoinfections.

Journal Article Type Article
Publication Date Aug 1, 2020
Journal Journal of Clinical Virology
Print ISSN 1386-6532
Electronic ISSN 1873-5967
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 129
Article Number 104453
APA6 Citation Bagasi, A. A., Howson-Wells, H. C., Clark, G., Tarr, A. W., Soo, S., Irving, W. L., & McClure, C. P. (2020). Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort. Journal of Clinical Virology, 129,
Keywords Human Bocavirus respiratory virus viral co-infection viral mono-infection viral bronchiolitis viral pneumonia
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