Is Single-Molecule Fluorescence Spectroscopy Ready To Join the Organic Chemistry Toolkit? A Test Case Involving Click Chemistry

Scaiano, Juan C.; Lanterna, Anabel E.

Abstract

Single molecule spectroscopy (SMS) has matured to a point where it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly applicable to catalytic systems where questions related to homogeneous vs heterogeneous pathways are important. SMS can look at intimate mechanistic details that can inspire major improvements of the catalyst performance, its recovery, and reuse. Here, we use the click reaction between alkynes and azides as an example where improvements at the bench have been inspired and validated using single-molecule fluorescence spectroscopy.

Citation

Scaiano, J. C., & Lanterna, A. E. (2017). Is Single-Molecule Fluorescence Spectroscopy Ready To Join the Organic Chemistry Toolkit? A Test Case Involving Click Chemistry. Journal of Organic Chemistry, 82(10), 5011-5019. https://doi.org/10.1021/acs.joc.6b03010

• Journal Article Type: Article
• Acceptance Date: Mar 28, 2017
• Online Publication Date: Apr 6, 2017
• Publication Date: May 19, 2017
• Deposit Date: Jun 22, 2020
• Publicly Available Date: Jul 21, 2020
• Journal: Journal of Organic Chemistry
• Print ISSN: 0022-3263
• Electronic ISSN: 1520-6904
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 82
• Issue: 10
• Pages: 5011-5019
• DOI: https://doi.org/10.1021/acs.joc.6b03010
• Public URL: https://nottingham-repository.worktribe.com/output/4442856
• Publisher URL: https://pubs.acs.org/doi/10.1021/acs.joc.6b03010
• Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry ,copyright© American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.joc.6b03010