Considering discrepancy when calibrating a mechanistic electrophysiology model

Wilkinson, Richard D.; Worden, Keith; Walmsley, John; Dos Santos, Rodrigo Weber; Riabiz, Marina; Pathmanathan, Pras; Panfilov, Alexander V.; Novaes, Gustavo Montes; Houston, Charles; Delhaas, Tammo; Cantwell, Chris D.; Beattie, Kylie A.; Aboelkassem, Yasser; Ghosh, Sanmitra; Lei, Chon Lok; Mirams, Gary R.; Whittaker, Dominic G.

Abstract

Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to explore and adopt UQ methods to characterize uncertainty in model inputs and how that propagates through to outputs or predictions; examples of this can be seen in the papers of this issue. In this review and perspective piece, we draw attention to an important and under-addressed source of uncertainty in our predictions-that of uncertainty in the model structure or the equations themselves. The difference between imperfect models and reality is termed model discrepancy, and we are often uncertain as to the size and consequences of this discrepancy. Here, we provide two examples of the consequences of discrepancy when calibrating models at the ion channel and action potential scales. Furthermore, we attempt to account for this discrepancy when calibrating and validating an ion channel model using different methods, based on modelling the discrepancy using Gaussian processes and autoregressive-moving-average models, then highlight the advantages and shortcomings of each approach. Finally, suggestions and lines of enquiry for future work are provided. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'.

Citation

Wilkinson, R. D., Worden, K., Walmsley, J., Dos Santos, R. W., Riabiz, M., Pathmanathan, P., Panfilov, A. V., Novaes, G. M., Houston, C., Delhaas, T., Cantwell, C. D., Beattie, K. A., Aboelkassem, Y., Ghosh, S., Lei, C. L., Mirams, G. R., & Whittaker, D. G. (2020). Considering discrepancy when calibrating a mechanistic electrophysiology model. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 378(2173), 20190349. https://doi.org/10.1098/rsta.2019.0349

• Journal Article Type: Article
• Acceptance Date: Apr 21, 2020
• Online Publication Date: May 25, 2020
• Publication Date: Jun 12, 2020
• Deposit Date: Apr 21, 2020
• Publicly Available Date: Apr 23, 2020
• Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
• Electronic ISSN: 1364-503X
• Publisher: The Royal Society
• Peer Reviewed: Peer Reviewed
• Volume: 378
• Issue: 2173
• Pages: 20190349
• DOI: https://doi.org/10.1098/rsta.2019.0349
• Keywords: General Engineering; General Physics and Astronomy; General Mathematics
• Public URL: https://nottingham-repository.worktribe.com/output/4324704
• Publisher URL: https://royalsocietypublishing.org/doi/10.1098/rsta.2019.0349
• Additional Information: Accepted: 2020-04-21; Published: 2020-05-25