Cell death pathology: Cross-talk with autophagy and its clinical implications

Amelio, Ivano; Melino, Gerry; Knight, Richard A.

Abstract

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, “autophagic cell death”. Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.

Citation

Amelio, I., Melino, G., & Knight, R. A. (2011). Cell death pathology: Cross-talk with autophagy and its clinical implications. Biochemical and Biophysical Research Communications, 414(2), 277-281. https://doi.org/10.1016/j.bbrc.2011.09.080

• Journal Article Type: Article
• Online Publication Date: Sep 21, 2011
• Publication Date: Oct 22, 2011
• Deposit Date: Apr 1, 2020
• Journal: Biochemical and Biophysical Research Communications
• Print ISSN: 0006-291X
• Electronic ISSN: 1090-2104
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 414
• Issue: 2
• Pages: 277-281
• DOI: https://doi.org/10.1016/j.bbrc.2011.09.080
• Public URL: https://nottingham-repository.worktribe.com/output/4237421
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0006291X11016846