Cell death pathology: Cross-talk with autophagy and its clinical implications

Amelio, Ivano; Melino, Gerry; Knight, Richard A.

Abstract

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, “autophagic cell death”. Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.

• Journal Article Type: Article
• Online Publication Date: Sep 21, 2011
• Publication Date: Oct 22, 2011
• Deposit Date: Apr 1, 2020
• Journal: Biochemical and Biophysical Research Communications
• Print ISSN: 0006-291X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 414
• Issue: 2
• Pages: 277-281
• DOI: https://doi.org/10.1016/j.bbrc.2011.09.080
• Public URL: https://nottingham-repository.worktribe.com/output/4237421
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0006291X11016846