p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

Pitolli, Consuelo; Wang, Ying; Candi, Eleonora; Shi, Yufang; Melino, Gerry; Amelio, Ivano

Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.

Citation

Pitolli, C., Wang, Y., Candi, E., Shi, Y., Melino, G., & Amelio, I. (2019). p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers, 11(12), Article 1983. https://doi.org/10.3390/cancers11121983

• Journal Article Type: Article
• Acceptance Date: Dec 4, 2019
• Online Publication Date: Dec 9, 2019
• Publication Date: Dec 9, 2019
• Deposit Date: Mar 31, 2020
• Publicly Available Date: Apr 1, 2020
• Journal: Cancers
• Electronic ISSN: 2072-6694
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 12
• Article Number: 1983
• DOI: https://doi.org/10.3390/cancers11121983
• Keywords: Cancer Research; Oncology
• Public URL: https://nottingham-repository.worktribe.com/output/4230891
• Publisher URL: https://www.mdpi.com/2072-6694/11/12/1983