Opioid pharmacology under the microscope

Jullé, Damien; Gondin, Arisbel B; Von Zastrow, Mark E; Canals, Meritxell

Abstract

The powerful analgesic effects of opioid drugs have captivated the interest of physicians and scientists for millennia, and the ability of opioid drugs to produce serious undesired effects has been recognized for a similar period of time (Kieffer and Evans, 2009). Many of these develop progressively with prolonged or repeated drug use and then persist, motivating particular interest in understanding how opioid drugs initiate adaptive or maladaptive modifications in neural function or regulation. Exciting advances have been made over the past several years in elucidating drug-induced changes at molecular, cellular, and physiologic scales of analysis. The present review will highlight some recent cellular studies that we believe bridge across scales and will focus on optical imaging approaches that put opioid drug action "under the microscope."

Citation

Jullé, D., Gondin, A. B., Von Zastrow, M. E., & Canals, M. (2020). Opioid pharmacology under the microscope. Molecular Pharmacology, 98(4), 425-432. https://doi.org/10.1124/mol.119.119321

• Journal Article Type: Article
• Acceptance Date: Mar 10, 2020
• Online Publication Date: Mar 20, 2020
• Publication Date: Oct 1, 2020
• Deposit Date: Mar 23, 2020
• Journal: Molecular Pharmacology
• Print ISSN: 0026-895X
• Electronic ISSN: 1521-0111
• Publisher: American Society for Pharmacology and Experimental Therapeutics
• Peer Reviewed: Peer Reviewed
• Volume: 98
• Issue: 4
• Pages: 425-432
• DOI: https://doi.org/10.1124/mol.119.119321
• Keywords: Molecular Medicine; Pharmacology
• Public URL: https://nottingham-repository.worktribe.com/output/4192548
• Publisher URL: https://molpharm.aspetjournals.org/content/98/4/425