Poly(Acrylic Acid)–Poly(Ethylene Glycol) Nanoparticles Designed for Ophthalmic Drug Delivery

Vasi, Ana-Maria; Popa, Marcel Ionel; Tanase, Edi Constantin; Butnaru, Maria; Verestiuc, Liliana

Abstract

Poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG), four-arm, amine-terminated particles with nanometer size and spherical shape were obtained by the polymers cross-linking, via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride, in a w/o emulsion. The morphology and surface charge of the final particles are strongly dependent on the molar ratio of PAA–PEG and the PAA concentration. The physicochemical characteristics correlated with the drug-loading capacity, in vitro and ex vivo release kinetics of pilocarpine hydrochloride and biocompatibility results indicate that these nanoparticles exhibit the prerequisite behavior for use as carriers of ophthalmic drugs.

Citation

Vasi, A.-M., Popa, M. I., Tanase, E. C., Butnaru, M., & Verestiuc, L. (2014). Poly(Acrylic Acid)–Poly(Ethylene Glycol) Nanoparticles Designed for Ophthalmic Drug Delivery. Journal of Pharmaceutical Sciences, 103(2), 676-686. https://doi.org/10.1002/jps.23793

• Journal Article Type: Article
• Acceptance Date: Oct 29, 2013
• Online Publication Date: Dec 19, 2013
• Publication Date: 2014-02
• Deposit Date: Apr 16, 2021
• Journal: Journal of Pharmaceutical Sciences
• Print ISSN: 0022-3549
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 103
• Issue: 2
• Pages: 676-686
• DOI: https://doi.org/10.1002/jps.23793
• Keywords: nanoparticlesophthalmic carrierspolymeric biomaterialspoly (acrylic acid)poly (ethylene glycol) four arms amine terminatedformulationw/o emulsionbiocompatibilitycontrolled release/delivery
• Public URL: https://nottingham-repository.worktribe.com/output/3961685
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0022354915306985