Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease

Tolomeo, Daniele; Micotti, Edoardo; Colombo Serra, Sonia; Chappell, Michael; Snellman, Anniina; Forloni, Gianluigi

Abstract

Glucose is the central nervous system’s only energy source. Imaging techniques capable to detect pathological alterations of the brain metabolism are useful in different diagnostic processes. Such techniques are also beneficial for assessing the evaluation efficacy of therapies in pre-clinical and clinical stages of diseases. Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a possible alternative to positron emission tomography (PET) imaging that has been widely explored in cancer research in humans and animal models. We propose that pathological alterations in brain 2-deoxy-D-glucose (2DG) uptake, typical of neurodegenerative diseases, can be detected with CEST MRI. Transgenic mice overexpressing a mutated form of amyloid precusrsor protein (APP23), a model of Alzheimer’s disease, analyzed with CEST MRI showed a clear reduction of 2DG uptake in different brain regions. This was reminiscent of the cerebral condition observed in Alzheimer’s patients. The results indicate the feasibility of CEST for analyzing the brain metabolic state, with better image resolution than PET in experimental models.

Citation

Tolomeo, D., Micotti, E., Colombo Serra, S., Chappell, M., Snellman, A., & Forloni, G. (2018). Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer’s Disease. Scientific Reports, 8, Article 9576. https://doi.org/10.1038/s41598-018-27839-7

• Journal Article Type: Article
• Acceptance Date: Jun 11, 2018
• Online Publication Date: Jun 22, 2018
• Publication Date: 2018-06
• Deposit Date: Jan 14, 2025
• Publicly Available Date: Jan 16, 2025
• Electronic ISSN: 2045-2322
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Article Number: 9576
• DOI: https://doi.org/10.1038/s41598-018-27839-7
• Public URL: https://nottingham-repository.worktribe.com/output/38648409
• Publisher URL: https://www.nature.com/articles/s41598-018-27839-7
• PMID: 29934551