Enhancing the potential of enantioselective organocatalysis with light

Melchiorre, Paolo; Silvi, Mattia

Abstract

© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Organocatalysis - catalysis mediated by small chiral organic molecules - is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electron-mediated chemistry and excited-state reactivity.

• Journal Article Type: Article
• Acceptance Date: Nov 24, 2017
• Online Publication Date: Feb 1, 2018
• Publication Date: 2018-02
• Deposit Date: Jan 29, 2020
• Publicly Available Date: Jan 31, 2020
• Journal: Nature
• Print ISSN: 0028-0836
• Electronic ISSN: 1476-4687
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 554
• Issue: 7690
• Pages: 41-49
• DOI: https://doi.org/10.1038/nature25175
• Keywords: Multidisciplinary
• Public URL: https://nottingham-repository.worktribe.com/output/3826615
• Publisher URL: https://www.nature.com/articles/nature25175
• Additional Information: Received: 8 August 2017; Accepted: 24 November 2017; First Online: 1 February 2018; : The authors declare no competing financial interests.