Transdermal delivery of glyceryl trinitrate: clinical applications in acute stroke

Appleton, Jason P; Krishnan, Kailash; Bath, Phiip M

Abstract

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Glyceryl trinitrate (GTN), a nitric oxide donor, is a candidate treatment for the management of acute stroke with hemodynamic and potential reperfusion and neuroprotective effects. Areas covered: Here we discuss the evidence to date from clinical trials and present and future possibilities for the clinical application of transdermal GTN in acute stroke. When administered as a transdermal patch during the acute and subacute phases after stroke, GTN was safe, lowered blood pressure, maintained cerebral blood flow, and did not induce cerebral steal or alter functional outcome. However, when given within the hyperacute phase (

Citation

Appleton, J. P., Krishnan, K., & Bath, P. M. (2020). Transdermal delivery of glyceryl trinitrate: clinical applications in acute stroke. Expert Opinion on Drug Delivery, 17(3), 297-303. https://doi.org/10.1080/17425247.2020.1716727

• Journal Article Type: Article
• Acceptance Date: Jan 13, 2020
• Online Publication Date: Jan 23, 2020
• Publication Date: Jan 23, 2020
• Deposit Date: Jan 24, 2020
• Publicly Available Date: Jan 24, 2021
• Journal: Expert Opinion on Drug Delivery
• Print ISSN: 1742-5247
• Electronic ISSN: 1744-7593
• Publisher: Taylor & Francis Open
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 3
• Pages: 297-303
• DOI: https://doi.org/10.1080/17425247.2020.1716727
• Keywords: Pharmaceutical Science
• Public URL: https://nottingham-repository.worktribe.com/output/3793121
• Publisher URL: https://www.tandfonline.com/doi/abs/10.1080/17425247.2020.1716727?journalCode=iedd20
• Additional Information: Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=iedd20; Received: 2019-11-20; Accepted: 2020-01-13; Published: 2020-01-23