High-throughput kinetics in drug discovery

Pinto, Maria Filipa; Sirina, Julija; Holliday, Nicholas D; McWhirter, Claire L

Abstract

The importance of a drug's kinetic profile and interplay of structure-kinetic activity with PK/PD has long been appreciated in drug discovery. However, technical challenges have often limited detailed kinetic characterization of compounds to the latter stages of projects. This review highlights the advances that have been made in recent years in techniques, instrumentation, and data analysis to increase the throughput of detailed kinetic and mechanistic characterization, enabling its application earlier in the drug discovery process.

Citation

Pinto, M. F., Sirina, J., Holliday, N. D., & McWhirter, C. L. (2024). High-throughput kinetics in drug discovery. Slas Discovery, 29(5), Article 100170. https://doi.org/10.1016/j.slasd.2024.100170

• Journal Article Type: Review
• Acceptance Date: Jun 17, 2024
• Online Publication Date: Jul 3, 2024
• Publication Date: Jul 1, 2024
• Deposit Date: Sep 6, 2024
• Publicly Available Date: Sep 13, 2024
• Journal: SLAS Discovery
• Print ISSN: 2472-5552
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 5
• Article Number: 100170
• DOI: https://doi.org/10.1016/j.slasd.2024.100170
• Public URL: https://nottingham-repository.worktribe.com/output/37139838