A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II

Matthews, F. E.; Stephan, B. C. M.; Robinson, L.; Jagger, C.; Barnes, L. E.; Arthur, A.; Brayne, C.

Abstract

Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline interviews in populations aged 65+ years in England and Wales (1989-1994). Three areas (CFAS I) were selected for new sampling two decades later (2008-2011) with same geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here we report a 20% drop in incidence (95% CI: 0-40%), driven by a reduction in men across all ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was uniquely designed to test for differences across geography and time. A reduction of age-specific incidence means that the numbers of people estimated to develop dementia in any year has remained relatively stable.

Citation

Matthews, F. E., Stephan, B. C. M., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., & Brayne, C. (2016). A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nature Communications, 7(1), Article 11398. https://doi.org/10.1038/ncomms11398

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2016
• Online Publication Date: Apr 19, 2016
• Publication Date: 2016-09
• Deposit Date: Nov 26, 2019
• Publicly Available Date: Nov 26, 2019
• Journal: Nature Communications
• Electronic ISSN: 2041-1723
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 1
• Article Number: 11398
• DOI: https://doi.org/10.1038/ncomms11398
• Keywords: General Biochemistry, Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/3417532
• Publisher URL: https://www.nature.com/articles/ncomms11398