Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity

Bemis, Thomas; Brychta, Robert; Chen, Kong�Y.; Courville, Amber; Crayner, Emma�J.; Goodwin, Stephanie; Guo, Juen; Howard, Lilian; Knuth, Nicolas�D.; Miller, Bernard�V.; Prado, Carla�M.; Siervo, Mario; Skarulis, Monica�C.; Walter, Mary; Walter, Peter�J.; Yannai, Laura; Hall, Kevin D.

Abstract

© 2015 Elsevier Inc. Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53 ± 6 g/day of body fat, fat oxidation was unchanged by fat restriction, leading to 89 ± 6 g/day of fat loss, and was significantly greater than carbohydrate restriction (p = 0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with prolonged isocaloric diets varying in carbohydrate and fat.

Citation

Bemis, T., Brychta, R., Chen, K., Courville, A., Crayner, E., Goodwin, S., Guo, J., Howard, L., Knuth, N., Miller, B., Prado, C., Siervo, M., Skarulis, M., Walter, M., Walter, P., Yannai, L., & Hall, K. D. (2015). Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metabolism, 22(3), 427-436. https://doi.org/10.1016/j.cmet.2015.07.021

• Journal Article Type: Article
• Acceptance Date: Jul 23, 2015
• Online Publication Date: Aug 13, 2015
• Publication Date: Sep 1, 2015
• Deposit Date: Nov 20, 2019
• Publicly Available Date: Nov 18, 2020
• Journal: Cell Metabolism
• Print ISSN: 1550-4131
• Electronic ISSN: 1932-7420
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 3
• Pages: 427-436
• DOI: https://doi.org/10.1016/j.cmet.2015.07.021
• Keywords: Cell Biology; Physiology; Molecular Biology
• Public URL: https://nottingham-repository.worktribe.com/output/3344851
• Publisher URL: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00350-2
• Additional Information: This article is maintained by: Elsevier; Article Title: Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity; Journal Title: Cell Metabolism; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.cmet.2015.07.021; Content Type: article; Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.