The physiologic benefits of optimizing cardiorespiratory fitness and physical activity – From the cell to systems level in a post-pandemic world

Faghy, Mark A.; Tatler, Amanda; Chidley, Corinna; Fryer, Simon; Stoner, Lee; Laddu, Deepika; Arena, Ross; Ashton, Ruth E.

Abstract

Cardiovascular (CV) disease (CVD) is a leading cause of premature death and hospitalization which places a significant strain on health services and economies around the World. Evidence from decades of empirical and observational research demonstrates clear associations between physical activity (PA) and cardiorespiratory fitness (CRF) which can offset the risk of mortality and increase life expectancy and the quality of life in patients. Whilst well documented, the narrative of increased CRF remained pertinent during the coronavirus disease 2019 (COVID-19) pandemic, where individuals with lower levels of CRF had more than double the risk of dying from COVID-19 compared to those with a moderate or high CRF. The need to better understand the mechanisms associated with COVID-19 and those that continue to be affected with persistent symptoms following infection (Long COVID), and CV health is key if we are to be able to effectively target the use of CRF and PA to improve the lives of those suffering its afflictions. Whilst there is a long way to go to optimise PA and CRF for improved health at a population level, particularly in a post-pandemic world, increasing the understanding using a cellular-to-systems approach, we hope to provide further insight into the benefits of engaging in PA.

Citation

Faghy, M. A., Tatler, A., Chidley, C., Fryer, S., Stoner, L., Laddu, D., …Ashton, R. E. (2024). The physiologic benefits of optimizing cardiorespiratory fitness and physical activity – From the cell to systems level in a post-pandemic world. Progress in Cardiovascular Diseases, 83, 49-54. https://doi.org/10.1016/j.pcad.2024.02.006

• Journal Article Type: Article
• Acceptance Date: Feb 24, 2024
• Online Publication Date: Feb 27, 2024
• Publication Date: 2024-03
• Deposit Date: May 22, 2024
• Publicly Available Date: May 24, 2024
• Journal: Progress in Cardiovascular Diseases
• Print ISSN: 0033-0620
• Electronic ISSN: 1873-1740
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 83
• Pages: 49-54
• DOI: https://doi.org/10.1016/j.pcad.2024.02.006
• Keywords: COVID-19, Cardio-respiratory fitness, Long COVID, Cardiovascular disease, Physical activity
• Public URL: https://nottingham-repository.worktribe.com/output/32736143
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0033062024000288?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: The physiologic benefits of optimizing cardiorespiratory fitness and physical activity – From the cell to systems level in a post-pandemic world; Journal Title: Progress in Cardiovascular Diseases; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.pcad.2024.02.006; Content Type: article; Copyright: © 2024 The Authors. Published by Elsevier Inc.