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Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Robertson, Karen; Flandrin, Pierre Baptiste; Klapwijk, Anneke R.; Wilson, Chick C.

Authors

Pierre Baptiste Flandrin

Anneke R. Klapwijk

Chick C. Wilson



Abstract

© 2016 American Chemical Society. The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.

Citation

Robertson, K., Flandrin, P. B., Klapwijk, A. R., & Wilson, C. C. (2016). Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC). Crystal Growth and Design, 16(8), 4759-4764. https://doi.org/10.1021/acs.cgd.6b00885

Journal Article Type Article
Acceptance Date Jul 11, 2016
Online Publication Date Jul 20, 2016
Publication Date Aug 3, 2016
Deposit Date Jan 11, 2020
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 16
Issue 8
Pages 4759-4764
DOI https://doi.org/10.1021/acs.cgd.6b00885
Keywords General Materials Science; General Chemistry; Condensed Matter Physics
Public URL https://nottingham-repository.worktribe.com/output/3235259