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Atrial cardiomyocyte calcium signalling

Bootman, Martin D.; Smyrnias, Ioannis; Thul, Rüdiger; Coombes, Stephen; Roderick, H. Llewelyn

Authors

Martin D. Bootman

Ioannis Smyrnias

H. Llewelyn Roderick



Abstract

Whereas Ca2+ signalling in ventricular cardiomyocytes is well described, much less is known regarding the Ca2+ signals within atrial cells. This is surprising given that atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, which enhances the subsequent ejection of blood from the heart. The dependence of cardiac function on the contribution of atria becomes increasingly important with age and exercise. Disruption of the rhythmic beating of atrial cardiomyocytes can lead to life-threatening conditions such as atrial fibrillation. Atrial and ventricular myocytes have many structural and functional similarities. However, one key structural difference, the lack of transverse tubules ("T-tubules") in atrial myocytes, make these two cell types display vastly different calcium patterns in response to electrical excitation. The lack of T-tubules in atrial myocytes means that depolarisation provokes calcium signals that originate around the periphery of the cells. Under resting conditions, such Ca2+ signals do not propagate towards the centre of the atrial cells and so do not fully engage the contractile machinery. Consequently, contraction of atrial myocytes under resting conditions is modest. However, when atrial myocytes are stimulated with a positive inotropic agonist, such as isoproterenol, the peripheral Ca2+ signals trigger a global wave of Ca2+ that propagates in a centripetal manner into the cells. Enhanced centripetal movement of Ca2+ in atrial myocytes leads to increased contraction and a more substantial contribution to blood pumping. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. © 2011 Elsevier B.V.

Citation

Bootman, M. D., Smyrnias, I., Thul, R., Coombes, S., & Roderick, H. L. (2011). Atrial cardiomyocyte calcium signalling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1813(5), 922-934. https://doi.org/10.1016/j.bbamcr.2011.01.030

Journal Article Type Review
Acceptance Date Jan 25, 2011
Online Publication Date Feb 4, 2011
Publication Date 2011-05
Deposit Date Sep 16, 2024
Journal Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Print ISSN 0167-4889
Electronic ISSN 1879-2596
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 1813
Issue 5
Pages 922-934
DOI https://doi.org/10.1016/j.bbamcr.2011.01.030
Public URL https://nottingham-repository.worktribe.com/output/3212759
Publisher URL https://www.sciencedirect.com/science/article/pii/S0167488911000383?via%3Dihub