Going Back to the Biology of FGF21: New Insights

Lewis, Jo E.; Ebling, Francis J.P.; Samms, Ricardo J.; Tsintzas, Kostas

Abstract

© 2019 Elsevier Ltd Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An improved understanding of the biological role of FGF21 may help to explain why its therapeutic potential in humans has not been fully realized. This review will cover the complexities in FGF21 biology in rodents and humans, with emphasis on its role in protection from central and peripheral facets of obesity.

Citation

Lewis, J. E., Ebling, F. J., Samms, R. J., & Tsintzas, K. (2019). Going Back to the Biology of FGF21: New Insights. Trends in Endocrinology and Metabolism, 30(8), 491-504. https://doi.org/10.1016/j.tem.2019.05.007

• Journal Article Type: Review
• Acceptance Date: May 30, 2019
• Online Publication Date: Jun 24, 2019
• Publication Date: Aug 1, 2019
• Deposit Date: Nov 18, 2019
• Publicly Available Date: Jun 25, 2020
• Journal: Trends in Endocrinology & Metabolism
• Print ISSN: 1043-2760
• Electronic ISSN: 1879-3061
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 8
• Pages: 491-504
• DOI: https://doi.org/10.1016/j.tem.2019.05.007
• Public URL: https://nottingham-repository.worktribe.com/output/3192847
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1043276019301067
• Additional Information: This article is maintained by: Elsevier; Article Title: Going Back to the Biology of FGF21: New Insights; Journal Title: Trends in Endocrinology & Metabolism; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.tem.2019.05.007; Content Type: article; Copyright: © 2019 Elsevier Ltd. All rights reserved.
• Contract Date: Nov 18, 2019