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Going Back to the Biology of FGF21: New Insights

Lewis, Jo E.; Ebling, Francis J.P.; Samms, Ricardo J.; Tsintzas, Kostas

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Authors

Jo E. Lewis

Francis J.P. Ebling

Ricardo J. Samms

KOSTAS TSINTZAS kostas.tsintzas@nottingham.ac.uk
Professor of Human Physiology



Abstract

© 2019 Elsevier Ltd Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An improved understanding of the biological role of FGF21 may help to explain why its therapeutic potential in humans has not been fully realized. This review will cover the complexities in FGF21 biology in rodents and humans, with emphasis on its role in protection from central and peripheral facets of obesity.

Citation

Lewis, J. E., Ebling, F. J., Samms, R. J., & Tsintzas, K. (2019). Going Back to the Biology of FGF21: New Insights. Trends in Endocrinology and Metabolism, 30(8), 491-504. https://doi.org/10.1016/j.tem.2019.05.007

Journal Article Type Review
Acceptance Date May 30, 2019
Online Publication Date Jun 24, 2019
Publication Date Aug 1, 2019
Deposit Date Nov 18, 2019
Publicly Available Date Mar 29, 2024
Journal Trends in Endocrinology & Metabolism
Print ISSN 1043-2760
Electronic ISSN 1879-3061
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 30
Issue 8
Pages 491-504
DOI https://doi.org/10.1016/j.tem.2019.05.007
Public URL https://nottingham-repository.worktribe.com/output/3192847
Publisher URL https://www.sciencedirect.com/science/article/pii/S1043276019301067
Additional Information This article is maintained by: Elsevier; Article Title: Going Back to the Biology of FGF21: New Insights; Journal Title: Trends in Endocrinology & Metabolism; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.tem.2019.05.007; Content Type: article; Copyright: © 2019 Elsevier Ltd. All rights reserved.