Evan Atlantis
Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS)
Atlantis, Evan; Martin, Sean A.; Haren, Matthew T.; O'Loughlin, Peter D.; Taylor, Anne W.; Anand-Ivell, Ravinder; Ivell, Richard; Wittert, Gary A.
Authors
Sean A. Martin
Matthew T. Haren
Peter D. O'Loughlin
Anne W. Taylor
RAVINDER ANAND-IVELL RAVINDER.ANAND-IVELL@NOTTINGHAM.AC.UK
Associate Professor
Richard Ivell
Gary A. Wittert
Abstract
Objective Plasma androgen levels are inversely associated with health in men, the age-related decline of which may result from factors other than ageing per se. This study aimed to determine the effects of demographic, physical and lifestyle factors on age-related androgen status in men. Design An observational survey of a regionally representative male population residing in the North West regions of Adelaide, Australia. Participants Study sample includes 1195 men aged 35-81 years with a response rate of 45·1%. Measurements Plasma levels of total testosterone (TT), bioavailable testosterone (BT), SHBG, insulin-like peptide 3 (INSL3), and gonadotrophins were measured along with an extensive list of demographic, physical and lifestyle factors including body composition, muscle strength and biomarkers of chronic diseases, physical activity, nutrition and smoking behaviour. Results Low TT was mostly associated with high abdominal fat and triglycerides and low muscle strength rather than ageing per se. Low BT was associated with increased age followed by high whole body fat percentage. BT and TT levels were higher in unmarried men and smokers. SHBG levels increased with age, but were also inversely associated with insulin and triglycerides. The Leydig cell specific factor INSL3 was the strongest biomarker associated with both TT and BT. Conclusions Factors associated with low androgen status variably include high body fat percentage, low muscle strength and biomarkers of the metabolic syndrome. Reducing exposure to factors that adversely affect androgen status may improve the general health of ageing men by mechanisms yet to be defined. © 2009 Blackwell Publishing Ltd.
Citation
Atlantis, E., Martin, S. A., Haren, M. T., O'Loughlin, P. D., Taylor, A. W., Anand-Ivell, R., …Wittert, G. A. (2009). Demographic, physical and lifestyle factors associated with androgen status: The Florey Adelaide Male Ageing Study (FAMAS). Clinical Endocrinology, 71(2), 261-272. https://doi.org/10.1111/j.1365-2265.2008.03463.x
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 20, 2008 |
Online Publication Date | Jul 6, 2009 |
Publication Date | Aug 1, 2009 |
Deposit Date | Jun 15, 2021 |
Journal | Clinical Endocrinology |
Print ISSN | 0300-0664 |
Electronic ISSN | 1365-2265 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 71 |
Issue | 2 |
Pages | 261-272 |
DOI | https://doi.org/10.1111/j.1365-2265.2008.03463.x |
Public URL | https://nottingham-repository.worktribe.com/output/3176554 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2008.03463.x |
Additional Information | Authors and the Members of the Florey Adelaide Male Ageing Study |
You might also like
Neohormones as biomarkers of reproductive health
(2013)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search