Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

Law, Mansun; Maruyama, Toshiaki; Lewis, Jamie; Giang, Erick; Tarr, Alexander W.; Stamataki, Zania; Gastaminza, Pablo; Chisari, Francis V.; Jones, Ian M.; Fox, Robert I.; Ball, Jonathan K.; McKeating, Jane A.; Kneteman, Norman M.; Burton, Dennis R.

Abstract

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver-chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable. © 2008 Nature Publishing Group.

Citation

Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M., Fox, R. I., Ball, J. K., McKeating, J. A., Kneteman, N. M., & Burton, D. R. (2008). Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nature Medicine, 14(1), 25-27. https://doi.org/10.1038/nm1698

• Journal Article Type: Article
• Acceptance Date: Nov 30, 2007
• Online Publication Date: Dec 6, 2007
• Publication Date: Jan 1, 2008
• Deposit Date: Nov 9, 2022
• Journal: Nature Medicine
• Print ISSN: 1078-8956
• Electronic ISSN: 1546-170X
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 1
• Pages: 25-27
• DOI: https://doi.org/10.1038/nm1698
• Public URL: https://nottingham-repository.worktribe.com/output/3129583
• Publisher URL: https://www.nature.com/articles/nm1698