Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study

Elneima, Omer; McAuley, Hamish J C; Leavy, Olivia C; Chalmers, James D; Horsley, Alex; Ho, Ling-Pei; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Harris, Victoria C; Houchen-Wolloff, Linzy; Saunders, Ruth M; Greening, Neil J; Richardson, Matthew; Quint, Jennifer K; Briggs, Andrew; Docherty, Annemarie B; Kerr, Steven; Harrison, Ewen M; Lone, Nazir I; Thorpe, Mathew; Heaney, Liam G; Lewis, Keir E; Aul, Raminder; Beirne, Paul; Bolton, Charlotte E; Brown, Jeremy S; Choudhury, Gourab; Diar Bakerly, Nawar; Easom, Nicholas; Echevarria, Carlos; Fuld, Jonathan; Hart, Nick; Hurst, John R; Jones, Mark G; Parekh, Dhruv; Pfeffer, Paul; Rahman, Najib M; Rowland-Jones, Sarah L; Roger Thompson, Aa; Jolley, Caroline; Shah, Ajay M; Wootton, Dan G; Chalder, Trudie; Davies, Melanie J; De Soyza, Anthony; Geddes, John R; Greenhalf, William; Heller, Simon; Howard, Luke S; Jacob, Joseph; Gisli Jenkins, R; Lord, Janet M; D-C Man, William; McCann, Gerry P;...

Abstract

The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalization, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments and to serve as a platform to enable future studies, including clinical trials.

Data collected covered a wide range of physical measures, biological samples and patient-reported outcome measures (PROMs).

Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA; or in Tier 2 in which they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at 5 (range 2–7) months and 12 (range 10–14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.

All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.

In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.

Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals from https://www.phosp.org/data-sample-request/.

Citation

Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V. C., Houchen-Wolloff, L., Saunders, R. M., Greening, N. J., Richardson, M., Quint, J. K., Briggs, A., Docherty, A. B., …Behalf of the PHOSP-COVID Collaborative Group, O. (2024). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1), Article dyad165. https://doi.org/10.1093/ije/dyad165

• Journal Article Type: Article
• Acceptance Date: Dec 7, 2023
• Online Publication Date: Dec 18, 2023
• Publication Date: Feb 1, 2024
• Deposit Date: Feb 29, 2024
• Publicly Available Date: Feb 29, 2024
• Journal: International Journal of Epidemiology
• Print ISSN: 0300-5771
• Electronic ISSN: 1464-3685
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 1
• Article Number: dyad165
• DOI: https://doi.org/10.1093/ije/dyad165
• Keywords: General Medicine, Epidemiology
• Public URL: https://nottingham-repository.worktribe.com/output/29257648
• Publisher URL: https://academic.oup.com/ije/article/53/1/dyad165/7477903