Harry Hill
The cost-effectiveness of risk-stratified breast cancer screening in the UK
Hill, Harry; Kearns, Ben; Pashayan, Nora; Roadevin, Cristina; Sasieni, Peter; Offman, Judith; Duffy, Stephen
Authors
Ben Kearns
Nora Pashayan
Dr CRISTINA ROADEVIN CRISTINA.ROADEVIN@NOTTINGHAM.AC.UK
HEALTH ECONOMIST
Peter Sasieni
Judith Offman
Stephen Duffy
Abstract
There has been growing interest in the UK and internationally of risk-stratified breast screening whereby individualised risk assessment may inform screening frequency, starting age, screening instrument used, or even decisions not to screen. This study evaluates the cost-effectiveness of eight proposals for risk-stratified screening regimens compared to both the current UK screening programme and no national screening. A person-level microsimulation model was developed to estimate health-related quality of life, cancer survival and NHS costs over the lifetime of the female population eligible for screening in the UK. Compared with both the current screening programme and no screening, risk-stratified regimens generated additional costs and QALYs, and had a larger net health benefit. The likelihood of the current screening programme being the optimal scenario was less than 1%. No screening amongst the lowest risk group, and triannual, biennial and annual screening amongst the three higher risk groups was the optimal screening strategy from those evaluated. We found that risk-stratified breast cancer screening has the potential to be beneficial for women at the population level, but the net health benefit will depend on the particular risk-based strategy. [Abstract copyright: © 2023. The Author(s).]
Citation
Hill, H., Kearns, B., Pashayan, N., Roadevin, C., Sasieni, P., Offman, J., & Duffy, S. (2023). The cost-effectiveness of risk-stratified breast cancer screening in the UK. British Journal of Cancer, 129(11), 1801-1809. https://doi.org/10.1038/s41416-023-02461-1
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 4, 2023 |
Online Publication Date | Oct 17, 2023 |
Publication Date | Nov 23, 2023 |
Deposit Date | Feb 13, 2025 |
Publicly Available Date | Mar 6, 2025 |
Print ISSN | 0007-0920 |
Electronic ISSN | 1532-1827 |
Publisher | Cancer Research UK |
Peer Reviewed | Peer Reviewed |
Volume | 129 |
Issue | 11 |
Pages | 1801-1809 |
DOI | https://doi.org/10.1038/s41416-023-02461-1 |
Public URL | https://nottingham-repository.worktribe.com/output/27069975 |
Publisher URL | https://www.nature.com/articles/s41416-023-02461-1 |
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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