Radiological classification of optic pathway gliomas: experience of a modified functional classification system

Walker, D; Benson, C; Ritzmann, T; Parker, T; Gregson, R; Milano, G; Jaspan, T; Taylor, T

doi:10.1259/bjr/65246351

Radiological classification of optic pathway gliomas: experience of a modified functional classification system

Walker, D; Benson, C; Ritzmann, T; Parker, T; Gregson, R; Milano, G; Jaspan, T; Taylor, T

Authors

D Walker

C Benson

Dr Timothy Ritzmann Timothy.Ritzmann1@nottingham.ac.uk
CLINICAL ASSOCIATE PROFESSOR

T Parker

R Gregson

G Milano

T Jaspan

T Taylor

Contributors

Timothy Ritzmann
Other

Abstract

Optic pathway gliomas (OPGs) in childhood are associated with neurofibromatosis type 1 (NF1) and since 1958 have been classified anatomically using the Dodge classification (DC). MR scanning permits a more detailed anatomical description than can be classified by this historical system. A modified Dodge classification (MDC) has been applied to MRI scans from a cohort of 72 patients (36.1% NF1-positive) from 4 centres participating in an international clinical trial. The MDC was feasible, applicable and more detailed than the original DC. NF1-positive cases more commonly involved both optic nerves (p = 0.021) and other multiple locations (p = 0.001). NF1-negative tumours more commonly involved the central chiasm (p = 0.005) and hypothalamus (p = 0.003). Fewer hypothalamus-positive tumours were associated with optic nerve involvement (p = 0.009), whereas more were associated with central chiasm involvement (p

Citation

Walker, D., Benson, C., Ritzmann, T., Parker, T., Gregson, R., Milano, G., Jaspan, T., & Taylor, T. (2008). Radiological classification of optic pathway gliomas: experience of a modified functional classification system. British Journal of Radiology, 81(970), 761-766. https://doi.org/10.1259/bjr/65246351

Journal Article Type	Article
Acceptance Date	Nov 19, 2007
Online Publication Date	Feb 13, 2014
Publication Date	2008-10
Deposit Date	Jan 18, 2021
Journal	British Journal of Radiology
Print ISSN	0007-1285
Electronic ISSN	1748-880X
Publisher	British Institute of Radiology
Peer Reviewed	Peer Reviewed
Volume	81
Issue	970
Pages	761-766
DOI	https://doi.org/10.1259/bjr/65246351
Keywords	Radiology Nuclear Medicine and imaging; General Medicine
Public URL	https://nottingham-repository.worktribe.com/output/2509454
Publisher URL	https://www.birpublications.org/doi/10.1259/bjr/65246351