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Radiological classification of optic pathway gliomas: experience of a modified functional classification system

Walker, D; Benson, C; Ritzmann, T; Parker, T; Gregson, R; Milano, G; Jaspan, T; Taylor, T

Authors

D Walker

C Benson

T Parker

R Gregson

G Milano

T Jaspan

T Taylor



Contributors

Timothy Ritzmann
Other

Abstract

Optic pathway gliomas (OPGs) in childhood are associated with neurofibromatosis type 1 (NF1) and since 1958 have been classified anatomically using the Dodge classification (DC). MR scanning permits a more detailed anatomical description than can be classified by this historical system. A modified Dodge classification (MDC) has been applied to MRI scans from a cohort of 72 patients (36.1% NF1-positive) from 4 centres participating in an international clinical trial. The MDC was feasible, applicable and more detailed than the original DC. NF1-positive cases more commonly involved both optic nerves (p = 0.021) and other multiple locations (p = 0.001). NF1-negative tumours more commonly involved the central chiasm (p = 0.005) and hypothalamus (p = 0.003). Fewer hypothalamus-positive tumours were associated with optic nerve involvement (p = 0.009), whereas more were associated with central chiasm involvement (p

Citation

Walker, D., Benson, C., Ritzmann, T., Parker, T., Gregson, R., Milano, G., …Taylor, T. (2008). Radiological classification of optic pathway gliomas: experience of a modified functional classification system. British Journal of Radiology, 81(970), 761-766. https://doi.org/10.1259/bjr/65246351

Journal Article Type Article
Acceptance Date Nov 19, 2007
Online Publication Date Feb 13, 2014
Publication Date 2008-10
Deposit Date Jan 18, 2021
Journal British Journal of Radiology
Print ISSN 0007-1285
Electronic ISSN 1748-880X
Publisher British Institute of Radiology
Peer Reviewed Peer Reviewed
Volume 81
Issue 970
Pages 761-766
DOI https://doi.org/10.1259/bjr/65246351
Keywords Radiology Nuclear Medicine and imaging; General Medicine
Public URL https://nottingham-repository.worktribe.com/output/2509454
Publisher URL https://www.birpublications.org/doi/10.1259/bjr/65246351


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