Skip to main content

Research Repository

See what's under the surface

The intra-tumoral stroma in patients with breast cancer increases with age

Vangangelt, K.M.H.; Kramer, C.J.H.; Bastiaannet, E.; Putter, H.; Cohen, D.; Van Pelt, G.W.; Rakha, E.A.; Green, A.R.; Tollenaar, R.A.E.M.; Mesker, W.E.

Authors

K.M.H. Vangangelt

C.J.H. Kramer

E. Bastiaannet

H. Putter

D. Cohen

G.W. Van Pelt

E.A. Rakha

A.R. Green

R.A.E.M. Tollenaar

W.E. Mesker



Abstract

Purpose
The tumor microenvironment in older patients is subject to changes. The tumor-stroma ratio (TSR) was evaluated in order to estimate the amount of intra-tumoral stroma and to evaluate the prognostic value of the TSR in older patients with breast cancer (≥70 years).

Methods
Two retrospective cohorts, the FOCUS study (N = 619) and the Nottingham Breast Cancer series (N = 1793), were used for assessment of the TSR on hematoxylin and eosin stained tissue slides.

Results
The intra-tumoral stroma increases with age in the FOCUS study and the Nottingham Breast Cancer series (B 0.031, 95% CI 0.006-0.057, P = 0.016 and B 0.034, 95% CI 0.015-0.054, P ≤ 0.001, respectively). Fifty-one percent of the patients from the Nottingham Breast Cancer series ≤40 years had a stroma-high tumor compared to 73% of the patients of ≥90 years from the FOCUS study. The TSR did not validate as an independent prognostic parameter in patients ≥70 years.

Conclusions
The intra-tumoral stroma increases with age. This might be the result of an activated tumor microenvironment. The TSR did not validate as an independent prognostic parameter in patients ≥70 years in contrast to young women with breast cancer as published previously.

Journal Article Type Article
Publication Date Sep 18, 2019
Journal Breast Cancer Research and Treatment
Print ISSN 0167-6806
Electronic ISSN 1573-7217
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Institution Citation Vangangelt, K., Kramer, C., Bastiaannet, E., Putter, H., Cohen, D., Van Pelt, G., …Mesker, W. (2019). The intra-tumoral stroma in patients with breast cancer increases with age. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05422-6
DOI https://doi.org/10.1007/s10549-019-05422-6
Publisher URL https://link.springer.com/article/10.1007/s10549-019-05422-6

Files







Downloadable Citations