Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function

Liu, Sai; Chen, Long; Li, Jinran; Sun, Yuan; Xu, Yue; Li, Zhaoxing; Zhu, Zheying; Li, Xinuo

Abstract

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of the pathogenesis of AD, strategies aimed at suppressing neuroinflammation and fostering synaptic repair are eagerly sought. Asiaticoside (AS), a natural triterpenoid derivative derived from Centella asiatica, is known for its anti-inflammatory, antioxidant, and wound-healing properties; however, its neuroprotective function in AD remains unclear. Our current study reveals that AS, when administered (40 mg/kg) in vivo, can mitigate cognitive dysfunction and attenuate neuroinflammation by inhibiting the activation of microglia and proinflammatory factors in Aβ1-42-induced AD mice. Further mechanistic investigation suggests that AS may ameliorate cognitive impairment by inhibiting the activation of the p38 MAPK pathway and promoting synaptic repair. Our findings propose that AS could be a promising candidate for AD treatment, offering neuroinflammation inhibition and enhancement of synaptic function.

Citation

Liu, S., Chen, L., Li, J., Sun, Y., Xu, Y., Li, Z., Zhu, Z., & Li, X. (2023). Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function. International Journal of Molecular Sciences, 24(15), Article 11976. https://doi.org/10.3390/ijms241511976

• Journal Article Type: Article
• Acceptance Date: Jul 24, 2023
• Online Publication Date: Jul 26, 2023
• Publication Date: 2023-08
• Deposit Date: Jul 29, 2023
• Publicly Available Date: Jul 31, 2023
• Journal: International Journal of Molecular Sciences
• Print ISSN: 1661-6596
• Electronic ISSN: 1422-0067
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 15
• Article Number: 11976
• DOI: https://doi.org/10.3390/ijms241511976
• Keywords: Alzheimer’s disease; Asiaticoside; synapse; inflammation; p38 MAPK
• Public URL: https://nottingham-repository.worktribe.com/output/23489104
• Publisher URL: https://www.mdpi.com/1422-0067/24/15/11976