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A novel high sensitivity bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis

Verma, Raman; Swift, Benjamin M.C.; Handley-Hartill, Wade; Lee, Joanne K.; Woltmann, Gerrit; Rees, Catherine E.D.; Haldar, Pranabashis

Authors

Raman Verma

Benjamin M.C. Swift

Wade Handley-Hartill

Joanne K. Lee

Gerrit Woltmann

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CATH REES cath.rees@nottingham.ac.uk
Professor of Microbiology

Pranabashis Haldar



Abstract

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompetent human cohorts, demonstrating associations of Mtb bacteraemia with progressive phenotypes of latent infection and active pulmonary TB respectively.

Citation

Verma, R., Swift, B. M., Handley-Hartill, W., Lee, J. K., Woltmann, G., Rees, C. E., & Haldar, P. (2020). A novel high sensitivity bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis. Clinical Infectious Diseases, 70(5), 933-936. https://doi.org/10.1093/cid/ciz548

Journal Article Type Article
Acceptance Date Jun 20, 2019
Online Publication Date Jun 22, 2019
Publication Date Mar 1, 2020
Deposit Date Aug 8, 2019
Publicly Available Date Mar 29, 2024
Journal Clinical Infectious Diseases
Print ISSN 1058-4838
Electronic ISSN 1537-6591
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 70
Issue 5
Pages 933-936
DOI https://doi.org/10.1093/cid/ciz548
Keywords Bacteriophage; Bacteremia; Human tuberculosis; Blood
Public URL https://nottingham-repository.worktribe.com/output/2302953
Publisher URL https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciz548/5522421
Additional Information This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record Raman Verma, Benjamin M C Swift, Wade Handley-Hartill, Joanne K Lee, Gerrit Woltmann, Catherine E D Rees, Pranabashis Haldar, A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis, Clinical Infectious Diseases, , ciz548is available online at: https://doi.org/10.1093/cid/ciz548