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Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis

Crooks, Colin J.; West, Joe; Morling, Joanne R.; Simmonds, Mark; Juurlink, Irene; Briggs, Steve; Cruickshank, Simon; Hammond-Pears, Susan; Shaw, Dominick; Card, Timothy R.; Marshall, Charles R.; Fogarty, Andrew W.

Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis Thumbnail


Authors

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinical Associate Professor

Mark Simmonds

Irene Juurlink

Steve Briggs

Simon Cruickshank

Susan Hammond-Pears

Dominick Shaw

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

Charles R. Marshall

ANDREW FOGARTY ANDREW.FOGARTY@NOTTINGHAM.AC.UK
Clinical Associate Professor & Reader in Clinical Epidemiology



Abstract

Objective
To explore the associations between arterial pO2, pCO2 and pH and how these are modified by age.

Methods
An analysis of 2598 patients admitted with a diagnosis of Covid-19 infection to a large UK teaching hospital.

Results
There were inverse associations for arterial pO2, pCO2 and pH with respiratory rate. The effects of pCO2 and pH on respiratory rate were modified by age; older patients had higher respiratory rates at higher pCO2 (p = 0.004) and lower pH (p = 0.007) values.

Conclusions
This suggests that ageing is associated with complex changes in the physiological feedback loops that control respiratory rate. As well as having clinical relevance, this may also impact on the use of respiratory rate in early warning scores across the age range.

Citation

Crooks, C. J., West, J., Morling, J. R., Simmonds, M., Juurlink, I., Briggs, S., …Fogarty, A. W. (2023). Respiratory rate responses to both hypercapnia and acidaemia are modified by age in patients with acidosis. Respiratory Physiology and Neurobiology, 315, Article 104098. https://doi.org/10.1016/j.resp.2023.104098

Journal Article Type Article
Acceptance Date Jun 25, 2023
Online Publication Date Jul 1, 2023
Publication Date 2023-09
Deposit Date Jul 6, 2023
Publicly Available Date Jul 6, 2023
Journal Respiratory Physiology and Neurobiology
Print ISSN 1569-9048
Electronic ISSN 1878-1519
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 315
Article Number 104098
DOI https://doi.org/10.1016/j.resp.2023.104098
Keywords Acidosis; oxygen; carbon dioxide; pH; respiratory rate
Public URL https://nottingham-repository.worktribe.com/output/22721455
Publisher URL https://www.sciencedirect.com/science/article/pii/S1569904823000861

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