Yan Yue
Dose and formulation of azithromycin in mass drug administration studies: a systematic review protocol
Yue, Yan; Xiong, Tao; Zeng, Linan; Choonara, Imti; Qazi, Shamim; Chen, Hongju; Mu, Dezhi
Authors
Tao Xiong
Linan Zeng
Imti Choonara
Shamim Qazi
Hongju Chen
Dezhi Mu
Abstract
Introduction: Azithromycin has been given for tropical infectious diseases such as trachoma and yaws by mass drug administration (MDA). As well as controlling the infectious disease in question, MDA may have a beneficial effect in reducing mortality in young children. However, the dose, formulation, frequency and duration of azithromycin used in certain infectious diseases may vary in different studies, and these differences may have impacts on the effectiveness of azithromycin MDA. Furthermore, whether the dose, formulation, frequency and duration are associated with the effectiveness of azithromycin for reducing child mortality—if indeed this effect can be confirmed—remain unknown. In this study, we will investigate whether different strategies such as different dose, formulation, frequency and duration affect the effectiveness of azithromycin MDA on the prevalence of certain infectious diseases or child mortality.
Methods and analysis: A narrative systematic review will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform will be searched. No language restrictions will be applied. All randomised/quasi-controlled trials, observational studies (cross-sectional studies, cohort studies and case–control studies), case series and registered protocols will be considered. Dose, duration, frequency, rounds and formulations of azithromycin used in MDA will be collected and reviewed. The outcomes will be disease prevalence/control in children and child mortality. Data from the individual studies will not be pooled.
Citation
Yue, Y., Xiong, T., Zeng, L., Choonara, I., Qazi, S., Chen, H., & Mu, D. (2019). Dose and formulation of azithromycin in mass drug administration studies: a systematic review protocol. BMJ Paediatrics Open, 3(1), Article e000462. https://doi.org/10.1136/bmjpo-2019-000462
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 29, 2019 |
Online Publication Date | May 30, 2019 |
Publication Date | May 30, 2019 |
Deposit Date | Jun 26, 2019 |
Publicly Available Date | Jun 26, 2019 |
Journal | BMJ Paediatrics Open |
Electronic ISSN | 2399-9772 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 3 |
Issue | 1 |
Article Number | e000462 |
DOI | https://doi.org/10.1136/bmjpo-2019-000462 |
Public URL | https://nottingham-repository.worktribe.com/output/2229564 |
Publisher URL | https://bmjpaedsopen.bmj.com/content/3/1/e000462 |
Contract Date | Jun 26, 2019 |
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Dose And Forumlation Of Azithromycin In Mass Drug Administration Studies (BMJPO Apr2019)
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