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Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis

Dazzan, Paola; Lappin, Julia M.; Heslin, Margaret; Donoghue, Kim; Lomas, Ben; Reininghaus, Uli; Onyejiaka, Adanna; Croudace, Tim; Jones, Peter B.; Murray, Robin M.; Fearon, Paul; Doody, Gillian A.; Morgan, Craig

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Authors

Paola Dazzan

Julia M. Lappin

Margaret Heslin

Kim Donoghue

Ben Lomas

Uli Reininghaus

Adanna Onyejiaka

Tim Croudace

Peter B. Jones

Robin M. Murray

Paul Fearon

Gillian A. Doody

Craig Morgan



Abstract

Background: To determine the baseline individual characteristics that predicted symptom recovery and functional recovery at 10-years following a first episode of psychosis.
Methods: AESOP-10 is a 10-year follow up of an epidemiological, naturalistic population-based cohort of individuals recruited at the time of their first episode of psychosis in two areas in the UK (South East London and Nottingham). Detailed information on demographic, clinical, and social factors was examined to identify which factors predicted symptom and functional remission and recovery over 10-year follow-up. The study included 557 individuals with a first episode psychosis. The main study outcomes were symptom recovery and functional recovery at 10-year follow-up.
Results: At 10 years, 46.2% (n=140 of 303) of patients achieved symptom recovery and 40.9% (n=117) achieved functional recovery. The strongest predictor of symptom recovery at 10 years was symptom remission at 12 weeks (adj OR=4.47; CI=2.60-7.67); followed by a diagnosis of depression with psychotic symptoms (adj OR=2.68; CI=1.02-7.05). Symptom remission at 12 weeks was also a strong predictor of functional recovery at 10 years (adj OR=2.75; CI=1.23-6.11), together with being from Nottingham study centre (adj OR=3.23; CI=1.25-8.30) and having a diagnosis of mania (adj OR=8.17; CI=1.61-41.42).
Conclusions: Symptom remission at 12 weeks is an important predictor of both symptom and functional recovery at 10 years, with implications for illness management. The concepts of clinical and functional recovery overlap but should be considered separately.

Citation

Dazzan, P., Lappin, J. M., Heslin, M., Donoghue, K., Lomas, B., Reininghaus, U., …Morgan, C. (2020). Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis. Psychological Medicine, 50(9), 1452-1462. https://doi.org/10.1017/S0033291719001399

Journal Article Type Article
Acceptance Date Jun 5, 2019
Online Publication Date Jul 25, 2019
Publication Date Jul 1, 2020
Deposit Date Jun 7, 2019
Publicly Available Date Mar 28, 2024
Journal Psychological Medicine
Print ISSN 0033-2917
Electronic ISSN 1469-8978
Publisher Cambridge University Press
Peer Reviewed Peer Reviewed
Volume 50
Issue 9
Pages 1452-1462
DOI https://doi.org/10.1017/S0033291719001399
Keywords Applied Psychology; Psychiatry and Mental health
Public URL https://nottingham-repository.worktribe.com/output/2159269
Publisher URL https://www.cambridge.org/core/journals/psychological-medicine/article/symptom-remission-at-12weeks-strongly-predicts-longterm-recovery-from-the-first-episode-of-psychosis/29FADB23F838FDC9466400412CD964ED

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