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3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells

Prasopthum, Aruna; Cooper, Mick; Shakesheff, Kevin M; Yang, Jing

Authors

Aruna Prasopthum

Mick Cooper

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JING YANG jing.yang@nottingham.ac.uk
Assistant Professor



Abstract

The effect of topography in 3D printed polymer scaffolds on stem cell differentiation is a significantly under-explored area. Compared to 2D biomaterials on which various well-defined topographies have been incorporated and been shown to direct an arrange of cell behaviours including adhesion, cytoskeleton organisation and differentiation, incorporating topographical features to 3D polymer scaffolds is challenging due to the difficulty of accessing the inside of a porous scaffold. Only roughened strut surface has been introduced to 3D printed porous

Journal Article Type Article
Publication Date May 29, 2019
Electronic ISSN 1944-8252
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 11
Issue 21
Pages 18896-18906
APA6 Citation Prasopthum, A., Cooper, M., Shakesheff, K. M., & Yang, J. (2019). 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells. ACS Applied Materials and Interfaces, 11(21), 18896-18906. doi:10.1021/acsami.9b01472
DOI https://doi.org/10.1021/acsami.9b01472
Keywords 3D printing; scaffolds; micro-/nano-pores; stem cells; differentiation
Publisher URL https://pubs.acs.org/doi/10.1021/acsami.9b01472
Additional Information This document is the unedited Author’s version of a SubmittedWork that was subsequently accepted for publication in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/toc/aamick/11/21