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A shared neural basis underlying psychiatric comorbidity

Xie, Chao; Xiang, Shitong; Shen, Chun; Peng, Xuerui; Kang, Jujiao; Li, Yuzhu; Cheng, Wei; He, Shiqi; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean Luc; Martinot, Marie Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H.; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Sahakian, Barbara J.; Robbins, Trevor W.; Schumann, Gunter; Jia, Tianye; Feng, Jianfeng; IMAGEN Consortium; STRATIFY Consortium; ZIB Consortium

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Authors

Chao Xie

Shitong Xiang

Chun Shen

Xuerui Peng

Jujiao Kang

Yuzhu Li

Wei Cheng

Shiqi He

Tobias Banaschewski

Gareth J. Barker

Arun L.W. Bokde

Uli Bromberg

Christian Büchel

Sylvane Desrivières

Herta Flor

Antoine Grigis

Hugh Garavan

Andreas Heinz

Bernd Ittermann

Jean Luc Martinot

Marie Laure Paillère Martinot

Frauke Nees

Dimitri Papadopoulos Orfanos

Tomáš Paus

Luise Poustka

Juliane H. Fröhner

Michael N. Smolka

Henrik Walter

Robert Whelan

Barbara J. Sahakian

Trevor W. Robbins

Gunter Schumann

Tianye Jia

Jianfeng Feng

IMAGEN Consortium

STRATIFY Consortium

ZIB Consortium



Abstract

Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.

Citation

Xie, C., Xiang, S., Shen, C., Peng, X., Kang, J., Li, Y., …ZIB Consortium. (2023). A shared neural basis underlying psychiatric comorbidity. Nature Medicine, 29(5), 1232-1242. https://doi.org/10.1038/s41591-023-02317-4

Journal Article Type Article
Acceptance Date Mar 20, 2023
Online Publication Date Apr 24, 2023
Publication Date 2023
Deposit Date Apr 12, 2023
Publicly Available Date Mar 28, 2024
Journal Nature Medicine
Print ISSN 1078-8956
Electronic ISSN 1546-170X
Publisher Springer Science and Business Media LLC
Peer Reviewed Peer Reviewed
Volume 29
Issue 5
Pages 1232-1242
DOI https://doi.org/10.1038/s41591-023-02317-4
Public URL https://nottingham-repository.worktribe.com/output/19458118
Publisher URL https://www.nature.com/articles/s41591-023-02317-4
Additional Information Received: 16 March 2022; Accepted: 20 March 2023; First Online: 24 April 2023; : T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH and Shire. He received conference support or speaker’s fee from Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire and Viforpharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to the above grants and relationships. G.J.B. received honoraria from General Electric Healthcare for teaching scanner programming courses. All other authors declare no competing interests.

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