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Effect of visual presentation of atherosclerotic carotid plaque on adherence to secondary preventive therapy using mHealth technologies (PreventiPlaque app): Study protocol for a randomized controlled trial

Ullrich, Greta; Dönmez, Alina; Mahabadi, Amir A.; Bäuerle, Alexander; Knuschke, Ramtin; Paldán, Katrin; Schnaubert, Lenka; Rammos, Christos; Rassaf, Tienush; Lortz, Julia

Authors

Greta Ullrich

Alina Dönmez

Amir A. Mahabadi

Alexander Bäuerle

Ramtin Knuschke

Katrin Paldán

Christos Rammos

Tienush Rassaf

Julia Lortz



Abstract

Background
Cardiovascular disease is the major cause of death worldwide. Although knowledge regarding diagnosing and treating cardiovascular disease has increased dramatically, secondary prevention remains insufficiently implemented due to failure among affected individuals to adhere to guideline recommendations. This has continued to lead to high morbidity and mortality rates. Involving patients in their healthcare and facilitating their active roles in their chronic disease management is an opportunity to meet the needs of the increasing number of cardiovascular patients. However, simple recall of advice regarding a more preventive lifestyle does not affect sustainable behavioral lifestyle changes. We investigate the effect of plaque visualization combined with low-threshold daily lifestyle tasks using the smartphone app PreventiPlaque to evaluate change in cardiovascular risk profile.
Methods
and study design: This randomized, controlled clinical trial includes 240 participants with ultrasound evidence of atherosclerotic plaque in one or both carotid arteries, defined as focal thickening of the vessel wall measuring 50% more than the regular vessel wall. A criterion for participation is access to a smartphone suitable for app usage. The participants are randomly assigned to an intervention or a control group. While both groups receive the standard of care, the intervention group has additional access to the PreventiPlaque app during the 12-month follow-up. The app includes daily tasks that promote a healthier lifestyle in the areas of smoking cessation, medication adherence, physical activity, and diet. The impact of plaque visualization and app use on the change in cardiovascular risk profile is assessed by SCORE2. Feasibility and effectiveness of the PreventiPlaque app are evaluated using standardized and validated measures for patient feedback.

Citation

Ullrich, G., Dönmez, A., Mahabadi, A. A., Bäuerle, A., Knuschke, R., Paldán, K., …Lortz, J. (2023). Effect of visual presentation of atherosclerotic carotid plaque on adherence to secondary preventive therapy using mHealth technologies (PreventiPlaque app): Study protocol for a randomized controlled trial. Heliyon, 9(3), Article e14052. https://doi.org/10.1016/j.heliyon.2023.e14052

Journal Article Type Article
Acceptance Date Feb 21, 2023
Online Publication Date Feb 27, 2023
Publication Date 2023-03
Deposit Date Mar 14, 2023
Publicly Available Date Mar 17, 2023
Journal Heliyon
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 9
Issue 3
Article Number e14052
DOI https://doi.org/10.1016/j.heliyon.2023.e14052
Keywords Cardiovascular diseases; Telemedicine; mHealth; Patient adherence
Public URL https://nottingham-repository.worktribe.com/output/18521524
Publisher URL https://www.cell.com/heliyon/fulltext/S2405-8440(23)01259-8
Related Public URLs https://www.sciencedirect.com/science/article/pii/S2405844023012598

Files

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Licence
https://creativecommons.org/licenses/by-nc-nd/4.0/

Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© 2023 The Authors. Published by Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. (https://creativecommons.org/licenses/by-nc-nd/4.0/)





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