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Effect of a Symbiotic Gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on Presence and Severity of Gastrointestinal Symptoms in Hemodialysis Patients

Viramontes-Hörner, Daniela; Márquez-Sandoval, Fabiola; Martín-del-Campo, Fabiola; Vizmanos-Lamotte, Barbara; Sandoval-Rodríguez, Ana; Armendáriz-Borunda, Juan; García-Bejarano, Héctor; Renoirte-López, Karina; García-García, Guillermo


Fabiola Márquez-Sandoval

Fabiola Martín-del-Campo

Barbara Vizmanos-Lamotte

Ana Sandoval-Rodríguez

Juan Armendáriz-Borunda

Héctor García-Bejarano

Karina Renoirte-López

Guillermo García-García


The study aimed to assess the effect of a symbiotic gel on presence and severity of gastrointestinal symptoms (GIS) in hemodialysis patients.

A double-blinded, placebo-controlled, randomized, clinical trial was designed. The study was conducted at 2 public hospitals in Guadalajara, Mexico.

Subjects and Intervention
Twenty-two patients were randomized to the intervention group (nutritional counseling + symbiotic gel) and 20 patients were randomized to the control group (nutritional counseling + placebo), during 2 months of follow-up.

Main Outcome Measure
Presence and monthly episodes of GIS were assessed by direct interview and severity by using the self-administered GIS questionnaire. Additionally, biochemical parameters, inflammatory markers, and nutritional status (dietary intake, subjective global assessment, anthropometry, and body composition) were evaluated.

After a 2-month treatment, intervention group had a significant reduction in prevalence and monthly episodes of vomit, heartburn, and stomachache, as well as a significant decrease in GIS severity compared with control group. Moreover, intervention group had a greater yet not significant decrease in the prevalence of malnutrition and a trend to reduce their C-reactive protein and tumor necrosis factor α levels compared with control group. No symbiotic-related adverse side effects were shown in these patients. Clinical studies with longer follow-up and sample size are needed to confirm these results.

We concluded that administration of a symbiotic gel is a safe and simple way to improve common GIS in dialysis patients.


Viramontes-Hörner, D., Márquez-Sandoval, F., Martín-del-Campo, F., Vizmanos-Lamotte, B., Sandoval-Rodríguez, A., Armendáriz-Borunda, J., …García-García, G. (2015). Effect of a Symbiotic Gel (Lactobacillus acidophilus + Bifidobacterium lactis + Inulin) on Presence and Severity of Gastrointestinal Symptoms in Hemodialysis Patients. Journal of Renal Nutrition, 25(3), 284-291.

Journal Article Type Article
Online Publication Date Nov 6, 2014
Publication Date 2015-05
Deposit Date Mar 6, 2023
Print ISSN 1051-2276
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 3
Pages 284-291
Keywords Nephrology; Nutrition and Dietetics; Medicine (miscellaneous)
Public URL
Publisher URL