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Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals’ exposure to non-tobacco nicotine: A systematic scoping review

Phillips, Lucy; Thomson, Ross; Coleman-Haynes, Tom; Cooper, Sue; Naughton, Felix; McDaid, Lisa; Emery, Joanne; Coleman, Tim

Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals’ exposure to non-tobacco nicotine: A systematic scoping review Thumbnail


Authors

Tom Coleman-Haynes

Felix Naughton

Lisa McDaid

Joanne Emery

TIM COLEMAN tim.coleman@nottingham.ac.uk
Professor of Primary Care



Contributors

Saeed Ahmed
Editor

Abstract

Introduction Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. As a first step towards summarising this literature, we undertook a systematic scoping review to determine the number and nature of offspring outcomes studied. Methods We searched MEDLINE and EMBASE databases for papers reporting empirical data on offspring outcomes following nicotine exposure to pregnant non-human mammals. We excluded studies that investigated exposure to only smoking, e-cigarettes, nicotine vaccines, or studies with no ‘nicotine only’ group. We developed a draft taxonomy and using this, described and quantified outcomes reported. Results We identified 476 studies, which reported 729 offspring outcomes. The draft taxonomy classified outcomes as being measured in i) whole animals, ii) body systems and iii) ‘other’. Body system outcomes were further categorised as being functional changes, or changes at macroscopic or cellular levels. The most frequently used outcomes were those detecting changes in the brain (n = 265), physical parameters measured in whole animals (n = 122) and any respiratory system changes (n = 97). Conclusions This scoping review quantifies the nature and frequency of outcomes used in preclinical studies investigating the potential impacts of nicotine administration in pregnancy on offspring. Systematic reviews of studies investigating outcomes involving animal brains, respiratory system, or ‘whole animal’ outcomes may have greatest potential for further advancing knowledge regarding impacts of gestational nicotine exposure on offspring.

Citation

Phillips, L., Thomson, R., Coleman-Haynes, T., Cooper, S., Naughton, F., McDaid, L., …Coleman, T. (2023). Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals’ exposure to non-tobacco nicotine: A systematic scoping review. PLoS ONE, 18(2), Article e0280805. https://doi.org/10.1371/journal.pone.0280805

Journal Article Type Article
Acceptance Date Jan 8, 2023
Online Publication Date Feb 3, 2023
Publication Date Feb 3, 2023
Deposit Date Feb 9, 2023
Publicly Available Date Feb 9, 2023
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science (PLoS)
Peer Reviewed Peer Reviewed
Volume 18
Issue 2
Article Number e0280805
DOI https://doi.org/10.1371/journal.pone.0280805
Keywords Multidisciplinary
Public URL https://nottingham-repository.worktribe.com/output/17081465
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280805