Skip to main content

Research Repository

Advanced Search

Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting

White, Victoria A.; Walker, Kate F.; Thornton, Jim G.

Authors

Victoria A. White

KATE WALKER Kate.Walker@nottingham.ac.uk
Clincial Associate Professor Inobstetrics / anne Mclaren Fellow

JIM THORNTON jim.thornton@nottingham.ac.uk
Professor of Obstetrics and Gynaecology



Abstract

Objective
To measure the extent to which the evidence underpinning prenatal corticosteroids for preterm fetal lung maturity is at risk of bias due to selective outcome reporting.
Study Design
Five biomedical databases (Medline, ClinicalTrials.gov, Embase, OVID and HMIC) were then searched for trials published between February 2016 and September 2017.
Randomised trials of prenatal steroids for women at risk of preterm birth were identified. For each, we recorded the registration status and timing, and whether the registered primary outcome had been reported. For unregistered trials, we estimated the potential for selective outcome reporting indirectly by tabulating all reported outcomes and by comparing the first outcome reported in the methods to the first in the results section.
Results
Twenty seven trials were identified. Only three (11%) trials had been registered. All three reported their pre-specified primary outcome. Among the unregistered trials, thirteen (54%) had different first reported outcomes in the methods and results sections, and among all trials many different outcomes were reported suggesting considerable potential for selective reporting. However, the single outcome of respiratory distress syndrome, albeit defined in different ways, was reported in all but two trials. This is reassuring evidence that the beneficial effect of steroids on this outcome has not been exaggerated by selective outcome reporting.
Conclusion
We conclude that the evidence that steroids reduce respiratory distress syndrome is secure.

Journal Article Type Article
Publication Date Mar 11, 2019
Journal European Journal of Obstetrics & Gynecology and Reproductive Biology
Print ISSN 0301-2115
Electronic ISSN 1872-7654
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 236
Pages 58-68
APA6 Citation White, V. A., Walker, K. F., & Thornton, J. G. (2019). Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting. European Journal of Obstetrics and Gynecology and Reproductive Biology, 236, 58-68. https://doi.org/10.1016/j.ejogrb.2019.02.031
DOI https://doi.org/10.1016/j.ejogrb.2019.02.031
Keywords Obstetrics and Gynaecology; Reproductive Medicine
Publisher URL https://www.sciencedirect.com/science/article/pii/S0301211519301034?via%3Dihub
;