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Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines

Adhikaree, Jason; Franks, Hester Ann; Televantos, Constantinos; Vaghela, Poonam; Kaur, Aanchal Preet; Walker, David; Schmitz, Marc; Jackson, Andrew; Patel, Poulam Manubhai

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines Thumbnail


Authors

Jason Adhikaree

HESTER FRANKS HESTER.FRANKS@NOTTINGHAM.AC.UK
Clinical Associate Professor/ anne Mclaren Fellowship

Constantinos Televantos

Poonam Vaghela

Aanchal Preet Kaur

David Walker

Marc Schmitz

POULAM PATEL POULAM.PATEL@NOTTINGHAM.AC.UK
Professor of Clinical Oncology



Abstract

Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumour immune responses. The greater potency of circulating dendritic cells (DC) over laboratory-generated monocyte-derived DC makes them exciting new immunotherapeutic candidates. To determine the immune status of GBM patients we initially investigated the frequency and function of circulating DC subsets. Furthermore, we tested the therapeutic potential of inhibiting the p38 mitogen-activated protein kinase pathway (p38i) in circulating DC to overcome DC dysfunction.
GBM patients (n=16) had significantly reduced numbers of the major myeloid circulating dendritic cell (cDC2) and plasmacytoid DC vs healthy controls; 1736 vs 4975 (p=0.028) and 893 vs 2287 cells/mL (P=

Citation

Adhikaree, J., Franks, H. A., Televantos, C., Vaghela, P., Kaur, A. P., Walker, D., …Patel, P. M. (2019). Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines. OncoImmunology, 8(7), 1-12. https://doi.org/10.1080/2162402X.2019.1593803

Journal Article Type Article
Acceptance Date Feb 28, 2019
Online Publication Date Apr 13, 2019
Publication Date Apr 13, 2019
Deposit Date Mar 1, 2019
Publicly Available Date Mar 28, 2024
Journal OncoImmunology
Print ISSN 2162-4011
Electronic ISSN 2162-402X
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 8
Issue 7
Article Number 1593803
Pages 1-12
DOI https://doi.org/10.1080/2162402X.2019.1593803
Keywords Immunology; Immunology and Allergy; Oncology
Public URL https://nottingham-repository.worktribe.com/output/1594839
Publisher URL https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1593803
Additional Information This is an Accepted Manuscript of an article published by Taylor & Francis in Oncoimmunology on 13.04.2019, available online: http://www.tandfonline.com/10.1080/2162402X.2019.1593803

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