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Living with chronic infection: Persistent immunomodulation during avirulent haemoparasitic infection in a wild rodent

Taylor, Christopher H.; Friberg, Ida M; Jackson, Joseph A.; Arriero, Elena; Begon, Mike; Wanelik, Klara M.; Paterson, Steve; Bradley, Janette E; Friberg, Ida M.; Bradley, Janette E.

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Authors

Ida M Friberg

Joseph A. Jackson

Elena Arriero

Mike Begon

Klara M. Wanelik

Steve Paterson

Janette E Bradley

Ida M. Friberg

Janette E. Bradley



Abstract

Apicomplexans are a protozoan phylum of obligate parasites which may be highly virulent during acute infections, but may also persist as chronic infections which appear to have little fitness cost. Babesia microti is an apicomplexan haemoparasite that, in immunocompromised individuals, can cause severe, potentially fatal disease. However, in its natural host, wild field voles (Microtus agrestis), it exhibits chronic infections that have no detectable impact on survival or female fecundity. How is damage minimized, and what is the impact on the host's immune state and health? We examine the differences in immune state (here represented by expression of immune‐related genes in multiple tissues) associated with several common chronic infections in a population of wild field voles. While some infections show little impact on immune state, we find strong associations between immune state and B. microti. These include indications of clearance of infected erythrocytes (increased macrophage activity in the spleen) and activity likely associated with minimizing damage from the infection (anti‐inflammatory and antioxidant activity in the blood). By analysing gene expression from the same individuals at multiple time points, we show that the observed changes are a response to infection, rather than a risk factor. Our results point towards continual investment to minimize the damage caused by the infection. Thus, we shed light on how wild animals can tolerate some chronic infections, but emphasize that this tolerance does not come without a cost.

Citation

Taylor, C. H., Friberg, I. M., Jackson, J. A., Arriero, E., Begon, M., Wanelik, K. M., …Bradley, J. E. (2023). Living with chronic infection: Persistent immunomodulation during avirulent haemoparasitic infection in a wild rodent. Molecular Ecology, 32(5), 1197-1210. https://doi.org/10.1111/mec.16819

Journal Article Type Article
Acceptance Date Nov 30, 2022
Online Publication Date Dec 8, 2022
Publication Date 2023-03
Deposit Date Feb 15, 2023
Publicly Available Date Feb 21, 2023
Journal Molecular Ecology
Print ISSN 0962-1083
Electronic ISSN 1365-294X
Peer Reviewed Peer Reviewed
Volume 32
Issue 5
Pages 1197-1210
DOI https://doi.org/10.1111/mec.16819
Keywords Babesia microti, chronic infection, immune state, longitudinal sampling, Microtus agrestis, wild immunology
Public URL https://nottingham-repository.worktribe.com/output/15431413
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/mec.16819

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Living with chronic infection: Persistent immunomodulation during avirulent haemoparasitic infection in a wild rodent (784 Kb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.




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