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Oligodendrogliogenesis and axon remyelination after traumatic spinal cord injuries in animal studies: a systematic review

Hassannejad, Zahra; Shakouri-Motlagh, Aida; Mokhatab, Mona; Abdollah Zadegan, Shayan; Sharif-Alhoseini, Mahdi; Shokraneh, Farhad; Rahimi-Movaghar, Vafa

Authors

Zahra Hassannejad

Aida Shakouri-Motlagh

Mona Mokhatab

Shayan Abdollah Zadegan

Mahdi Sharif-Alhoseini

Farhad Shokraneh

Vafa Rahimi-Movaghar



Abstract

© 2019 IBRO Extensive oligodendrocyte death after acute traumatic spinal cord injuries (TSCI) leads to axon demyelination and subsequently may leave axons vulnerable to degeneration. Despite the present evidence showing spontaneous remyelination after TSCI the cellular origin of new myelin and the time course of the axon ensheathment/remyelination remained controversial issue. In this systematic review the trend of oligodendrocyte death after injury as well as the extent and the cellular origin of oligodendrogliogenesis were comprehensively evaluated. The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided systematic review. PubMed and EMBASE were searched with no temporal or linguistic restrictions. Also, hand-search was performed in the bibliographies of relevant articles. Non-interventional animal studies discussing different types of myelinating cells including oligodendrocytes, Schwann cells and oligodendrocyte progenitor cells (OPCs) were evaluated. The extent of oligodendrocyte death, oligodendrocyte differentiation and remyelination were the pathophysiological outcome measures. We found 12,359 studies, 34 of which met the inclusion criteria. The cumulative evidence shows extensive oligodendrocytes cell death during the first week post-injury (pi). OPCs and peripheral invading Schwann cells are the dominant cells contributing in myelin formation. The maximum OPC proliferation was observed at around 2 weeks pi and oligodendrogliogenesis continues at later stages until the number of oligodendrocytes return to normal tissue by one month pi. Taken together, the evidence in animals reveals the potential role for endogenous myelinating cells in the axon ensheathment/remyelination after TSCI and this can be the target of pharmacotherapy to induce oligodendrocyte differentiation and myelin formation post-injury.

Journal Article Type Article
Publication Date Jan 24, 2019
Journal Neuroscience
Print ISSN 0306-4522
Electronic ISSN 1873-7544
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 402
Pages 37-50
APA6 Citation Hassannejad, Z., Shakouri-Motlagh, A., Mokhatab, M., Abdollah Zadegan, S., Sharif-Alhoseini, M., Shokraneh, F., & Rahimi-Movaghar, V. (2019). Oligodendrogliogenesis and axon remyelination after traumatic spinal cord injuries in animal studies: a systematic review. Neuroscience, 402, 37-50. https://doi.org/10.1016/j.neuroscience.2019.01.019
DOI https://doi.org/10.1016/j.neuroscience.2019.01.019
Keywords General Neuroscience
Publisher URL https://www.sciencedirect.com/science/article/pii/S0306452219300399?via%3Dihub

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