Integrated plug flow synthesis and crystallisation of pyrazinamide

Scott, C. Daniel; Labes, Ricardo; Depardieu, Martin; Battilocchio, Claudio; Davidson, Matthew G.; Ley, Steven V.; Wilson, Chick C.; Robertson, Karen

Abstract

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

Citation

Scott, C. D., Labes, R., Depardieu, M., Battilocchio, C., Davidson, M. G., Ley, S. V., Wilson, C. C., & Robertson, K. (2018). Integrated plug flow synthesis and crystallisation of pyrazinamide. Reaction Chemistry and Engineering, 3(5), 631-634. https://doi.org/10.1039/c8re00087e

• Journal Article Type: Article
• Acceptance Date: Jul 3, 2018
• Online Publication Date: Jul 10, 2018
• Publication Date: Oct 1, 2018
• Deposit Date: Jan 17, 2019
• Journal: Reaction Chemistry & Engineering
• Print ISSN: 2058-9883
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 5
• Pages: 631-634
• DOI: https://doi.org/10.1039/c8re00087e
• Public URL: https://nottingham-repository.worktribe.com/output/1480357
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2018/re/c8re00087e#!divAbstract