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Integrated plug flow synthesis and crystallisation of pyrazinamide

Scott, C. Daniel; Labes, Ricardo; Depardieu, Martin; Battilocchio, Claudio; Davidson, Matthew G.; Ley, Steven V.; Wilson, Chick C.; Robertson, Karen


C. Daniel Scott

Ricardo Labes

Martin Depardieu

Claudio Battilocchio

Matthew G. Davidson

Steven V. Ley

Chick C. Wilson


We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.


Scott, C. D., Labes, R., Depardieu, M., Battilocchio, C., Davidson, M. G., Ley, S. V., …Robertson, K. (2018). Integrated plug flow synthesis and crystallisation of pyrazinamide. Reaction Chemistry and Engineering, 3(5), 631-634.

Journal Article Type Article
Acceptance Date Jul 3, 2018
Online Publication Date Jul 10, 2018
Publication Date Oct 1, 2018
Deposit Date Jan 17, 2019
Journal Reaction Chemistry & Engineering
Print ISSN 2058-9883
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 3
Issue 5
Pages 631-634
Public URL
Publisher URL!divAbstract